Cargando…

miR-140-5p Aggravates Insulin Resistance via Directly Targeting GYS1 and PPP1CC in Insulin-Resistant HepG2 Cells

BACKGROUND: Much attention has been paid to the regulatory role of microRNA (miRNA) in insulin resistance. Nevertheless, how miR-140-5p regulates insulin resistance remains unclear. In this research, we aim to investigate the roles of miR-140-5p in insulin resistance. METHODS: qRT-PCR is used to ana...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xuemei, Ye, Yan, Wang, Baoli, Zhao, Shujun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2021
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187005/ https://www.ncbi.nlm.nih.gov/pubmed/34113143 http://dx.doi.org/10.2147/DMSO.S304055

Ejemplares similares

GYS1 or PPP1R3C deficiency rescues murine adult polyglucosan body disease
por: Chown, Erin E., et al.
Publicado: (2020)

The Mechanism by Which Amentoflavone Improves Insulin Resistance in HepG2 Cells
por: Zheng, Xiaoke, et al.
Publicado: (2016)

Resveratrol metabolites ameliorate insulin resistance in HepG2 hepatocytes by modulating IRS-1/AMPK
por: Teng, Wendi, et al.
Publicado: (2018)

Effects of Traditional Chinese Medicinal Plants on Anti-insulin Resistance Bioactivity of DXMS-Induced Insulin Resistant HepG2 Cells
por: Ma, Jun-Zeng, et al.
Publicado: (2014)

Astragalus polysaccharide ameliorates insulin resistance in HepG2 cells through activating the STAT5/IGF‐1 pathway
por: Yue, Xinxin, et al.
Publicado: (2023)

4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-α and regulating the expression of insulin signal transduction proteins
por: GAO, FENG, et al.
Publicado: (2015)

Effects of daphnetin on lipid metabolism, insulin resistance and oxidative stress in OA-treated HepG2 cells
por: Liu, Yayun, et al.
Publicado: (2019)

The Effects and Regulatory Mechanism of Casein-Derived Peptide VLPVPQK in Alleviating Insulin Resistance of HepG2 Cells
por: Li, Dapeng, et al.
Publicado: (2023)

Diosgenin and 5-Methoxypsoralen Ameliorate Insulin Resistance through ER-α/PI3K/Akt-Signaling Pathways in HepG2 Cells
por: Fang, Ke, et al.
Publicado: (2016)

Paliurus spina-christi Mill fruit extracts improve glucose uptake and activate the insulin signaling pathways in HepG2 insulin-resistant cells
por: Esfahani, Seyedeh Mona Mousavi, et al.
Publicado: (2023)

miR-93-5p promotes insulin resistance to regulate type 2 diabetes progression in HepG2 cells by targeting HGF
por: Zhou, Man, et al.
Publicado: (2021)

Depressive Symptoms, Antidepressant Medication Use, and Insulin Resistance: The PPP-Botnia Study
por: Pyykkönen, Antti-Jussi, et al.
Publicado: (2011)

Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells
por: Chen, Jin-Wun, et al.
Publicado: (2018)

Scallop mantle extract inhibits insulin signaling in HepG2 cells
por: Kariya, Takahide, et al.
Publicado: (2019)

Astragaloside IV Inhibits Triglyceride Accumulation in Insulin-Resistant HepG2 Cells via AMPK-Induced SREBP-1c Phosphorylation
por: Wang, Chunyi, et al.
Publicado: (2018)

Water Extract of Mungbean (Vigna radiata L.) Inhibits Protein Tyrosine Phosphatase-1B in Insulin-Resistant HepG2 Cells
por: Saeting, Orathai, et al.
Publicado: (2021)

Significant Expression Levels of Transgenic PPP1CC2 in Testis and Sperm Are Required to Overcome the Male Infertility Phenotype of Ppp1cc Null Mice
por: Sinha, Nilam, et al.
Publicado: (2012)

Qizhi Jiangtang Jiaonang Improves Insulin Signaling and Reduces Inflammatory Cytokine Secretion and Reactive Oxygen Species Formation in Insulin Resistant HepG2 Cells
por: Zhang, Xiao-Tian, et al.
Publicado: (2015)

Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells
por: Kim, Ok-Kyung, et al.
Publicado: (2016)

Combination Treatment of Deep Sea Water and Fucoidan Attenuates High Glucose-Induced Insulin-Resistance in HepG2 Hepatocytes
por: He, Shan, et al.
Publicado: (2018)

Wu-Mei-Wan Reduces Insulin Resistance via Inhibition of NLRP3 Inflammasome Activation in HepG2 Cells
por: Yang, Xueping, et al.
Publicado: (2017)

Statins Aggravate the Risk of Insulin Resistance in Human Muscle
por: Grunwald, Stefanie A., et al.
Publicado: (2022)

Triterpenoid Saponins from Stauntonia chinensis Ameliorate Insulin Resistance via the AMP-Activated Protein Kinase and IR/IRS-1/PI3K/Akt Pathways in Insulin-Resistant HepG2 Cells
por: Hu, Xin, et al.
Publicado: (2014)

Oleanolic Acid Attenuates Insulin Resistance via NF-κB to Regulate the IRS1-GLUT4 Pathway in HepG2 Cells
por: Li, Ming, et al.
Publicado: (2015)

PP1γ regulates neuronal insulin signaling and aggravates insulin resistance leading to AD-like phenotypes
por: Yadav, Yamini, et al.
Publicado: (2023)

Variation in GYS1 Interacts with Exercise and Gender to Predict Cardiovascular Mortality
por: Fredriksson, Jenny, et al.
Publicado: (2007)

Data in support of fumosorinone, a novel PTP1B inhibitor, activates insulin signaling in insulin-resistance HepG2 cells and shows anti-diabetic effect in diabetic KKAy mice
por: Luo, Du-Qiang, et al.
Publicado: (2015)

Postprandial triglyceride-rich lipoproteins induce hepatic insulin resistance in HepG2 cells independently of their receptor-mediated cellular uptake
por: Tatarczyk, Tobias, et al.
Publicado: (2011)

Palmitate-induced insulin resistance is attenuated by Pioglitazone and EGCG through reducing the gluconeogenic key enzymes expression in HepG2 cells
por: Yadollah, S, et al.
Publicado: (2017)

Galangin and Pinocembrin from Propolis Ameliorate Insulin Resistance in HepG2 Cells via Regulating Akt/mTOR Signaling
por: Liu, Yinkang, et al.
Publicado: (2018)

Ultrasonic-Cellulase Synergistic Extraction of Crude Polysaccharides from Moringa oleifera Leaves and Alleviation of Insulin Resistance in HepG2 Cells
por: Gu, Fan, et al.
Publicado: (2022)

Subjective Sleep Complaints Are Associated With Insulin Resistance in Individuals Without Diabetes: The PPP-Botnia Study
por: Pyykkönen, Antti-Jussi, et al.
Publicado: (2012)

Patulin Alters Insulin Signaling and Metabolic Flexibility in HepG2 and HEK293 Cells
por: Pillay, Yashodani, et al.
Publicado: (2023)

Mangiferin Improved Palmitate-Induced-Insulin Resistance by Promoting Free Fatty Acid Metabolism in HepG2 and C2C12 Cells via PPARα: Mangiferin Improved Insulin Resistance
por: Zhang, Qiao, et al.
Publicado: (2019)

Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway
por: Wu, Yang Sheng, et al.
Publicado: (2020)

Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
por: Park, Jae-Yeo, et al.
Publicado: (2015)

Geniposide promotes autophagy to inhibit insulin resistance in HepG2 cells via P62/NF-κB/GLUT-4
por: Jiang, Hongwei, et al.
Publicado: (2017)

Potential activities and mechanisms of extracellular polysaccharopeptides from fermented Trametes versicolor on regulating glucose homeostasis in insulin-resistant HepG2 cells
por: Teng, Ju-Fang, et al.
Publicado: (2018)

Flavonoids from Camellia sinensis (L.) O. Kuntze seed ameliorates TNF-α induced insulin resistance in HepG2 cells
por: Chen, Fu-Chih, et al.
Publicado: (2019)

Combined Use of Astragalus Polysaccharide and Berberine Attenuates Insulin Resistance in IR-HepG2 Cells via Regulation of the Gluconeogenesis Signaling Pathway
por: Mao, Zhu-Jun, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_p8fi30j9b7fm9cpdqjft2ujjfr