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Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19
The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the confirmed patients impaired with significant complications, including multi-organ failure. Acute respiratory distress imposed by SARS-CoV-2 l...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187014/ https://www.ncbi.nlm.nih.gov/pubmed/34102081 http://dx.doi.org/10.1098/rsob.210069 |
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author | Cheema, Pradeep Singh Nandi, Deeptashree Nag, Alo |
author_facet | Cheema, Pradeep Singh Nandi, Deeptashree Nag, Alo |
author_sort | Cheema, Pradeep Singh |
collection | PubMed |
description | The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the confirmed patients impaired with significant complications, including multi-organ failure. Acute respiratory distress imposed by SARS-CoV-2 largely results from an aggravated cytokine storm and deregulated immune response. The forkhead box O (FoxO) transcription factors are reported to play a significant role in maintaining normal cell physiology by regulating survival, apoptosis, oxidative stress, development and maturation of T and B lymphocytes, secretion of inflammatory cytokines, etc. We propose a potent anti-inflammatory approach based on activation of the FoxO as an attractive strategy against the novel coronavirus. This regime will be focused on restoring redox and inflammatory homeostasis along with repair of the damaged tissue, activation of lymphocyte effector and memory cells. Repurposing FoxO activators as a means to alleviate the inflammatory burst following SARS-CoV-2 infection can prove immensely valuable in the ongoing pandemic and provide a reliable groundwork for enriching our repertoire of antiviral modalities for any such complication in the future. Altogether, our review highlights the possible efficacy of FoxO activation as a novel arsenal for clinical management of COVID-19. |
format | Online Article Text |
id | pubmed-8187014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-81870142021-06-09 Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 Cheema, Pradeep Singh Nandi, Deeptashree Nag, Alo Open Biol Review The COVID-19 pandemic has wreaked unprecedented societal havoc worldwide. The infected individuals may present mild to severe symptoms, with nearly 20% of the confirmed patients impaired with significant complications, including multi-organ failure. Acute respiratory distress imposed by SARS-CoV-2 largely results from an aggravated cytokine storm and deregulated immune response. The forkhead box O (FoxO) transcription factors are reported to play a significant role in maintaining normal cell physiology by regulating survival, apoptosis, oxidative stress, development and maturation of T and B lymphocytes, secretion of inflammatory cytokines, etc. We propose a potent anti-inflammatory approach based on activation of the FoxO as an attractive strategy against the novel coronavirus. This regime will be focused on restoring redox and inflammatory homeostasis along with repair of the damaged tissue, activation of lymphocyte effector and memory cells. Repurposing FoxO activators as a means to alleviate the inflammatory burst following SARS-CoV-2 infection can prove immensely valuable in the ongoing pandemic and provide a reliable groundwork for enriching our repertoire of antiviral modalities for any such complication in the future. Altogether, our review highlights the possible efficacy of FoxO activation as a novel arsenal for clinical management of COVID-19. The Royal Society 2021-06-09 /pmc/articles/PMC8187014/ /pubmed/34102081 http://dx.doi.org/10.1098/rsob.210069 Text en © 2021 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Review Cheema, Pradeep Singh Nandi, Deeptashree Nag, Alo Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title | Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title_full | Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title_fullStr | Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title_full_unstemmed | Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title_short | Exploring the therapeutic potential of forkhead box O for outfoxing COVID-19 |
title_sort | exploring the therapeutic potential of forkhead box o for outfoxing covid-19 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187014/ https://www.ncbi.nlm.nih.gov/pubmed/34102081 http://dx.doi.org/10.1098/rsob.210069 |
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