Cargando…

Methanol poisoning as a new world challenge: A review

BACKGROUND: Methanol poisoning (MP) occurs often via ingestion, inhalation, or dermal exposure to formulations containing methanol in base. Clinical manifestations of MP include gastrointestinal symptoms, central nervous system (CNS) suppression, and decompensated metabolic acidosis occurred with bl...

Descripción completa

Detalles Bibliográficos
Autores principales: Nekoukar, Zahra, Zakariaei, Zakaria, Taghizadeh, Fatemeh, Musavi, Fatemeh, Banimostafavi, Elham Sadat, Sharifpour, Ali, Ebrahim Ghuchi, Nasrin, Fakhar, Mahdi, Tabaripour, Rabeeh, Safanavaei, Sepideh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187162/
https://www.ncbi.nlm.nih.gov/pubmed/34141419
http://dx.doi.org/10.1016/j.amsu.2021.102445
_version_ 1783705087475974144
author Nekoukar, Zahra
Zakariaei, Zakaria
Taghizadeh, Fatemeh
Musavi, Fatemeh
Banimostafavi, Elham Sadat
Sharifpour, Ali
Ebrahim Ghuchi, Nasrin
Fakhar, Mahdi
Tabaripour, Rabeeh
Safanavaei, Sepideh
author_facet Nekoukar, Zahra
Zakariaei, Zakaria
Taghizadeh, Fatemeh
Musavi, Fatemeh
Banimostafavi, Elham Sadat
Sharifpour, Ali
Ebrahim Ghuchi, Nasrin
Fakhar, Mahdi
Tabaripour, Rabeeh
Safanavaei, Sepideh
author_sort Nekoukar, Zahra
collection PubMed
description BACKGROUND: Methanol poisoning (MP) occurs often via ingestion, inhalation, or dermal exposure to formulations containing methanol in base. Clinical manifestations of MP include gastrointestinal symptoms, central nervous system (CNS) suppression, and decompensated metabolic acidosis occurred with blurred vision and early or late blindness. OBJECTIVE: This study reviewed the clinical manifestations, laboratory and radiology findings, and treatment approaches in MP. DISCUSSION: Methanol is usually rapidly absorbed after ingestion and metabolized by alcohol dehydrogenase (ADH), then distributed to the body water to reach a volume distribution approximately equal to 0.77 L/kg. It is also eliminated from the body as unchanged parent compounds. Clinical manifestations of MP alone initiate within 0.5–4 h after ingestion and include gastrointestinal symptoms and CNS suppression. After a latent period of 6–24 h, depending on the absorbed dose, decompensated metabolic acidosis occurs with blurred vision and early or late blindness. Blurred vision with normal consciousness is a strong suspicious sign of an MP. The mortality and severity of intoxication are well associated with the severity of CNS depression, hyperglycemia, and metabolic acidosis, but not with serum methanol concentration. After initial resuscitation, the most important therapeutic action for patients with known or suspected MP is correction of acidosis, inhibition of ADH, and hemodialysis. CONCLUSION: Since MP is associated with high morbidity and mortality, it should be considered seriously and instantly managed. Delay in treatment may cause complications, permanent damage, and even death.
format Online
Article
Text
id pubmed-8187162
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-81871622021-06-16 Methanol poisoning as a new world challenge: A review Nekoukar, Zahra Zakariaei, Zakaria Taghizadeh, Fatemeh Musavi, Fatemeh Banimostafavi, Elham Sadat Sharifpour, Ali Ebrahim Ghuchi, Nasrin Fakhar, Mahdi Tabaripour, Rabeeh Safanavaei, Sepideh Ann Med Surg (Lond) Review BACKGROUND: Methanol poisoning (MP) occurs often via ingestion, inhalation, or dermal exposure to formulations containing methanol in base. Clinical manifestations of MP include gastrointestinal symptoms, central nervous system (CNS) suppression, and decompensated metabolic acidosis occurred with blurred vision and early or late blindness. OBJECTIVE: This study reviewed the clinical manifestations, laboratory and radiology findings, and treatment approaches in MP. DISCUSSION: Methanol is usually rapidly absorbed after ingestion and metabolized by alcohol dehydrogenase (ADH), then distributed to the body water to reach a volume distribution approximately equal to 0.77 L/kg. It is also eliminated from the body as unchanged parent compounds. Clinical manifestations of MP alone initiate within 0.5–4 h after ingestion and include gastrointestinal symptoms and CNS suppression. After a latent period of 6–24 h, depending on the absorbed dose, decompensated metabolic acidosis occurs with blurred vision and early or late blindness. Blurred vision with normal consciousness is a strong suspicious sign of an MP. The mortality and severity of intoxication are well associated with the severity of CNS depression, hyperglycemia, and metabolic acidosis, but not with serum methanol concentration. After initial resuscitation, the most important therapeutic action for patients with known or suspected MP is correction of acidosis, inhibition of ADH, and hemodialysis. CONCLUSION: Since MP is associated with high morbidity and mortality, it should be considered seriously and instantly managed. Delay in treatment may cause complications, permanent damage, and even death. Elsevier 2021-06-02 /pmc/articles/PMC8187162/ /pubmed/34141419 http://dx.doi.org/10.1016/j.amsu.2021.102445 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nekoukar, Zahra
Zakariaei, Zakaria
Taghizadeh, Fatemeh
Musavi, Fatemeh
Banimostafavi, Elham Sadat
Sharifpour, Ali
Ebrahim Ghuchi, Nasrin
Fakhar, Mahdi
Tabaripour, Rabeeh
Safanavaei, Sepideh
Methanol poisoning as a new world challenge: A review
title Methanol poisoning as a new world challenge: A review
title_full Methanol poisoning as a new world challenge: A review
title_fullStr Methanol poisoning as a new world challenge: A review
title_full_unstemmed Methanol poisoning as a new world challenge: A review
title_short Methanol poisoning as a new world challenge: A review
title_sort methanol poisoning as a new world challenge: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187162/
https://www.ncbi.nlm.nih.gov/pubmed/34141419
http://dx.doi.org/10.1016/j.amsu.2021.102445
work_keys_str_mv AT nekoukarzahra methanolpoisoningasanewworldchallengeareview
AT zakariaeizakaria methanolpoisoningasanewworldchallengeareview
AT taghizadehfatemeh methanolpoisoningasanewworldchallengeareview
AT musavifatemeh methanolpoisoningasanewworldchallengeareview
AT banimostafavielhamsadat methanolpoisoningasanewworldchallengeareview
AT sharifpourali methanolpoisoningasanewworldchallengeareview
AT ebrahimghuchinasrin methanolpoisoningasanewworldchallengeareview
AT fakharmahdi methanolpoisoningasanewworldchallengeareview
AT tabaripourrabeeh methanolpoisoningasanewworldchallengeareview
AT safanavaeisepideh methanolpoisoningasanewworldchallengeareview