IGFBP-1 expression is reduced in human type 2 diabetic glomeruli and modulates β1-integrin/FAK signalling in human podocytes

AIMS/HYPOTHESIS: Podocyte loss or injury is one of the earliest features observed in the pathogenesis of diabetic kidney disease (DKD), which is the leading cause of end-stage renal failure worldwide. Dysfunction in the IGF axis, including in IGF binding proteins (IGFBPs), is associated with DKD, pa...

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Detalles Bibliográficos
Autores principales: Lay, Abigail C., Hale, Lorna J., Stowell-Connolly, Holly, Pope, Robert J. P., Nair, Viji, Ju, Wenjun, Marquez, Eva, Rollason, Ruth, Hurcombe, Jenny A., Hayes, Bryony, Roberts, Timothy, Gillam, Lawrence, Allington, Jonathan, Nelson, Robert G., Kretzler, Matthias, Holly, Jeff M. P., Perks, Claire M., McArdle, Craig A., Welsh, Gavin I., Coward, Richard J. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187213/
https://www.ncbi.nlm.nih.gov/pubmed/33758952
http://dx.doi.org/10.1007/s00125-021-05427-1

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