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Stationary distributions via decomposition of stochastic reaction networks
We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such networks is in general hard, both analytically and by simulation. In particular, stationary distributions of stochastic reaction networks are only known in some cases. We anal...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Berlin Heidelberg
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187217/ https://www.ncbi.nlm.nih.gov/pubmed/34101026 http://dx.doi.org/10.1007/s00285-021-01620-3 |
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author | Hoessly, Linard |
author_facet | Hoessly, Linard |
author_sort | Hoessly, Linard |
collection | PubMed |
description | We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such networks is in general hard, both analytically and by simulation. In particular, stationary distributions of stochastic reaction networks are only known in some cases. We analyze class properties of the underlying continuous-time Markov chain of CRNs under the operation of join and examine conditions such that the form of the stationary distributions of a CRN is derived from the parts of the decomposed CRNs. The conditions can be easily checked in examples and allow recursive application. The theory developed enables sequential decomposition of the Markov processes and calculations of stationary distributions. Since the class of processes expressible through such networks is big and only few assumptions are made, the principle also applies to other stochastic models. We give examples of interest from CRN theory to highlight the decomposition. |
format | Online Article Text |
id | pubmed-8187217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-81872172021-06-11 Stationary distributions via decomposition of stochastic reaction networks Hoessly, Linard J Math Biol Article We examine reaction networks (CRNs) through their associated continuous-time Markov processes. Studying the dynamics of such networks is in general hard, both analytically and by simulation. In particular, stationary distributions of stochastic reaction networks are only known in some cases. We analyze class properties of the underlying continuous-time Markov chain of CRNs under the operation of join and examine conditions such that the form of the stationary distributions of a CRN is derived from the parts of the decomposed CRNs. The conditions can be easily checked in examples and allow recursive application. The theory developed enables sequential decomposition of the Markov processes and calculations of stationary distributions. Since the class of processes expressible through such networks is big and only few assumptions are made, the principle also applies to other stochastic models. We give examples of interest from CRN theory to highlight the decomposition. Springer Berlin Heidelberg 2021-06-08 2021 /pmc/articles/PMC8187217/ /pubmed/34101026 http://dx.doi.org/10.1007/s00285-021-01620-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hoessly, Linard Stationary distributions via decomposition of stochastic reaction networks |
title | Stationary distributions via decomposition of stochastic reaction networks |
title_full | Stationary distributions via decomposition of stochastic reaction networks |
title_fullStr | Stationary distributions via decomposition of stochastic reaction networks |
title_full_unstemmed | Stationary distributions via decomposition of stochastic reaction networks |
title_short | Stationary distributions via decomposition of stochastic reaction networks |
title_sort | stationary distributions via decomposition of stochastic reaction networks |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187217/ https://www.ncbi.nlm.nih.gov/pubmed/34101026 http://dx.doi.org/10.1007/s00285-021-01620-3 |
work_keys_str_mv | AT hoesslylinard stationarydistributionsviadecompositionofstochasticreactionnetworks |