Cargando…
The role of diet in the pathophysiology and management of irritable bowel syndrome
Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Wes...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187226/ https://www.ncbi.nlm.nih.gov/pubmed/33666892 http://dx.doi.org/10.1007/s12664-020-01144-6 |
_version_ | 1783705101167230976 |
---|---|
author | El-Salhy, Magdy Patcharatrakul, Tanisa Gonlachanvit, Sutep |
author_facet | El-Salhy, Magdy Patcharatrakul, Tanisa Gonlachanvit, Sutep |
author_sort | El-Salhy, Magdy |
collection | PubMed |
description | Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Western countries, which might explain differences in the prevalence, sex, and clinical presentation seen between patients with IBS in Asian and Western countries. Dietary regimes such as a low-fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) diet and the modified National Institute for Health and Care Excellence (NICE) diet improve both symptoms and the quality of life in a considerable proportion of IBS patients. It has been speculated that diet is a prebiotic for the intestinal microbiota and favors the growth of certain bacteria. These bacteria ferment the dietary components, and the products of fermentation act upon intestinal stem cells to influence their differentiation into enteroendocrine cells. The resulting low density of enteroendocrine cells accompanied by low levels of certain hormones gives rise to intestinal dysmotility, visceral hypersensitivity, and abnormal secretion. This hypothesis is supported by the finding that changing to a low-FODMAP diet restores the density of GI cells to the levels in healthy subjects. These changes in gut endocrine cells caused by low-FODMAP diet are also accompanied by improvements in symptoms and the quality of life. |
format | Online Article Text |
id | pubmed-8187226 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-81872262021-06-11 The role of diet in the pathophysiology and management of irritable bowel syndrome El-Salhy, Magdy Patcharatrakul, Tanisa Gonlachanvit, Sutep Indian J Gastroenterol Review Article Irritable bowel syndrome (IBS) is a chronic gastrointestinal (GI) disorder that reportedly affects 5% to 20% of the world population. The etiology of IBS is not completely understood, but diet appears to play an important role in its pathophysiology. Asian diets differ considerably from those in Western countries, which might explain differences in the prevalence, sex, and clinical presentation seen between patients with IBS in Asian and Western countries. Dietary regimes such as a low-fermentable oligo-, di-, monosaccharides, and polyols (FODMAP) diet and the modified National Institute for Health and Care Excellence (NICE) diet improve both symptoms and the quality of life in a considerable proportion of IBS patients. It has been speculated that diet is a prebiotic for the intestinal microbiota and favors the growth of certain bacteria. These bacteria ferment the dietary components, and the products of fermentation act upon intestinal stem cells to influence their differentiation into enteroendocrine cells. The resulting low density of enteroendocrine cells accompanied by low levels of certain hormones gives rise to intestinal dysmotility, visceral hypersensitivity, and abnormal secretion. This hypothesis is supported by the finding that changing to a low-FODMAP diet restores the density of GI cells to the levels in healthy subjects. These changes in gut endocrine cells caused by low-FODMAP diet are also accompanied by improvements in symptoms and the quality of life. Springer India 2021-03-05 2021 /pmc/articles/PMC8187226/ /pubmed/33666892 http://dx.doi.org/10.1007/s12664-020-01144-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article El-Salhy, Magdy Patcharatrakul, Tanisa Gonlachanvit, Sutep The role of diet in the pathophysiology and management of irritable bowel syndrome |
title | The role of diet in the pathophysiology and management of irritable bowel syndrome |
title_full | The role of diet in the pathophysiology and management of irritable bowel syndrome |
title_fullStr | The role of diet in the pathophysiology and management of irritable bowel syndrome |
title_full_unstemmed | The role of diet in the pathophysiology and management of irritable bowel syndrome |
title_short | The role of diet in the pathophysiology and management of irritable bowel syndrome |
title_sort | role of diet in the pathophysiology and management of irritable bowel syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187226/ https://www.ncbi.nlm.nih.gov/pubmed/33666892 http://dx.doi.org/10.1007/s12664-020-01144-6 |
work_keys_str_mv | AT elsalhymagdy theroleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome AT patcharatrakultanisa theroleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome AT gonlachanvitsutep theroleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome AT elsalhymagdy roleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome AT patcharatrakultanisa roleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome AT gonlachanvitsutep roleofdietinthepathophysiologyandmanagementofirritablebowelsyndrome |