A Novel Stable Isotope Approach Demonstrates Surprising Degree of Age-Related Decline in Skeletal Muscle Collagen Proteostasis

Age-related deterioration in turnover of collagen proteins accelerates extracellular matrix fibrosis and hinders adaptation to external stimuli. This project sought to understand factors that increase skeletal muscle fibrosis with age by studying what we term the dynamic protein pool. We hypothesize...

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Detalles Bibliográficos
Autores principales: Abbott, Claire B, Lawrence, Marcus M, Kobak, Kamil A, Lopes, Erika Barboza Prado, Peelor, Frederick F, Donald, Elizabeth J, Van Remmen, Holly, Griffin, Timothy M, Miller, Benjamin F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187230/
https://www.ncbi.nlm.nih.gov/pubmed/34124684
http://dx.doi.org/10.1093/function/zqab028

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