Disruptin, a cell-penetrating peptide degrader of EGFR: Cell-Penetrating Peptide in Cancer Therapy

Disruptin is a cell-permeable decoy peptide designed to destabilize activated EGFR, both by inhibiting Hsp90 chaperoning and dissociating the active asymmetric EGFR dimer, which leads to an increase in engagement of activated EGFR with the proteolytic degradation machinery and subsequent loss from t...

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Detalles Bibliográficos
Autores principales: Mehta, Ranjit K., Shukla, Sushmita, Ramanand, Susmita G., Somnay, Vishal, Bridges, Alexander J., Lawrence, Theodore S., Nyati, Mukesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187233/
https://www.ncbi.nlm.nih.gov/pubmed/34107419
http://dx.doi.org/10.1016/j.tranon.2021.101140

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