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Antiviral strategies targeting herpesviruses

Herpesviruses, known as large DNA viruses, have a wide host range. In addition to human beings, cattle, and horses, even carp can be hosts for herpesvirus infection. Herpesviruses are pathogens possessing elaborate mechanisms that regulate host cell components for its replication, assembly and gener...

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Detalles Bibliográficos
Autores principales: Dong, Haisi, Wang, Zeyu, Zhao, Daqing, Leng, Xiangyang, Zhao, Yicheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187247/
https://www.ncbi.nlm.nih.gov/pubmed/34141443
http://dx.doi.org/10.1016/j.jve.2021.100047
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author Dong, Haisi
Wang, Zeyu
Zhao, Daqing
Leng, Xiangyang
Zhao, Yicheng
author_facet Dong, Haisi
Wang, Zeyu
Zhao, Daqing
Leng, Xiangyang
Zhao, Yicheng
author_sort Dong, Haisi
collection PubMed
description Herpesviruses, known as large DNA viruses, have a wide host range. In addition to human beings, cattle, and horses, even carp can be hosts for herpesvirus infection. Herpesviruses are pathogens possessing elaborate mechanisms that regulate host cell components for its replication, assembly and generating mature virus particles that can infect humans and most animals, usually causing multiple and lifelong infections. In addition, several human diseases, such as genital or mouth herpes, mononucleosis, and Burkitt lymphoma, are usually associated with herpesvirus infection. Blocking the steps of viral infection, such as entry, replication and assembly, may be an effective way for many different herpes viruses and their related diseases. Therefore, we aim to describe antiviral agents that are able to prevent herpesvirus entry, replication and assembly in host cells. We summarize antiviral strategies, including certain small molecular drugs, RNA interference and CRISPR/Cas9 system-based antiviral approaches, which represent promising approaches.
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spelling pubmed-81872472021-06-16 Antiviral strategies targeting herpesviruses Dong, Haisi Wang, Zeyu Zhao, Daqing Leng, Xiangyang Zhao, Yicheng J Virus Erad Review Herpesviruses, known as large DNA viruses, have a wide host range. In addition to human beings, cattle, and horses, even carp can be hosts for herpesvirus infection. Herpesviruses are pathogens possessing elaborate mechanisms that regulate host cell components for its replication, assembly and generating mature virus particles that can infect humans and most animals, usually causing multiple and lifelong infections. In addition, several human diseases, such as genital or mouth herpes, mononucleosis, and Burkitt lymphoma, are usually associated with herpesvirus infection. Blocking the steps of viral infection, such as entry, replication and assembly, may be an effective way for many different herpes viruses and their related diseases. Therefore, we aim to describe antiviral agents that are able to prevent herpesvirus entry, replication and assembly in host cells. We summarize antiviral strategies, including certain small molecular drugs, RNA interference and CRISPR/Cas9 system-based antiviral approaches, which represent promising approaches. Elsevier 2021-05-30 /pmc/articles/PMC8187247/ /pubmed/34141443 http://dx.doi.org/10.1016/j.jve.2021.100047 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Dong, Haisi
Wang, Zeyu
Zhao, Daqing
Leng, Xiangyang
Zhao, Yicheng
Antiviral strategies targeting herpesviruses
title Antiviral strategies targeting herpesviruses
title_full Antiviral strategies targeting herpesviruses
title_fullStr Antiviral strategies targeting herpesviruses
title_full_unstemmed Antiviral strategies targeting herpesviruses
title_short Antiviral strategies targeting herpesviruses
title_sort antiviral strategies targeting herpesviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187247/
https://www.ncbi.nlm.nih.gov/pubmed/34141443
http://dx.doi.org/10.1016/j.jve.2021.100047
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