Cargando…
Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40
Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages (Mϕs). Consistent with a pro-tumor role of IL-6 in alternative Mϕs polarization, we here show that targeting IL-6 by genetic...
Autores principales: | Yang, Fan, He, Zhenqiang, Duan, Hao, Zhang, Duo, Li, Juehui, Yang, Huijuan, Dorsey, Jay F., Zou, Wei, Nabavizadeh, S. Ali, Bagley, Stephen J., Abdullah, Kalil, Brem, Steven, Zhang, Lin, Xu, Xiaowei, Byrne, Katelyn T., Vonderheide, Robert H., Gong, Yanqing, Fan, Yi |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187342/ https://www.ncbi.nlm.nih.gov/pubmed/34103524 http://dx.doi.org/10.1038/s41467-021-23832-3 |
Ejemplares similares
-
PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma
por: Liu, Tianrun, et al.
Publicado: (2018) -
BIMG-12. [18F]FLUCICLOVINE PET TO DISTINGUISH PSEUDOPROGRESSION FROM TUMOR PROGRESSION IN POST-TREATMENT GLIOBLASTOMA
por: Nabavizadeh, Ali, et al.
Publicado: (2021) -
Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma
por: Makhlin, Igor, et al.
Publicado: (2019) -
(18)F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling
por: Henderson, Fraser, et al.
Publicado: (2020) -
Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α
por: Wang, Qirui, et al.
Publicado: (2018)