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Risk score to stratify miscarriage risk levels in preconception women

Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivar...

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Autores principales: Choo, Xin Hui, Ku, Chee Wai, Cheung, Yin Bun, Godfrey, Keith M., Chong, Yap-Seng, Shek, Lynette Pei-Chi, Tan, Kok Hian, Tan, Thiam Chye, Nadarajah, Sadhana, Yap, Fabian Kok Peng, Colega, Marjorelee T., Chong, Mary Foong-Fong, Chan, Shiao-Yng, Loy, See Ling, Chan, Jerry Kok Yen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187346/
https://www.ncbi.nlm.nih.gov/pubmed/34103654
http://dx.doi.org/10.1038/s41598-021-91567-8
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author Choo, Xin Hui
Ku, Chee Wai
Cheung, Yin Bun
Godfrey, Keith M.
Chong, Yap-Seng
Shek, Lynette Pei-Chi
Tan, Kok Hian
Tan, Thiam Chye
Nadarajah, Sadhana
Yap, Fabian Kok Peng
Colega, Marjorelee T.
Chong, Mary Foong-Fong
Chan, Shiao-Yng
Loy, See Ling
Chan, Jerry Kok Yen
author_facet Choo, Xin Hui
Ku, Chee Wai
Cheung, Yin Bun
Godfrey, Keith M.
Chong, Yap-Seng
Shek, Lynette Pei-Chi
Tan, Kok Hian
Tan, Thiam Chye
Nadarajah, Sadhana
Yap, Fabian Kok Peng
Colega, Marjorelee T.
Chong, Mary Foong-Fong
Chan, Shiao-Yng
Loy, See Ling
Chan, Jerry Kok Yen
author_sort Choo, Xin Hui
collection PubMed
description Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage.
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spelling pubmed-81873462021-06-09 Risk score to stratify miscarriage risk levels in preconception women Choo, Xin Hui Ku, Chee Wai Cheung, Yin Bun Godfrey, Keith M. Chong, Yap-Seng Shek, Lynette Pei-Chi Tan, Kok Hian Tan, Thiam Chye Nadarajah, Sadhana Yap, Fabian Kok Peng Colega, Marjorelee T. Chong, Mary Foong-Fong Chan, Shiao-Yng Loy, See Ling Chan, Jerry Kok Yen Sci Rep Article Spontaneous miscarriage is one of the most common complications of pregnancy. Even though some risk factors are well documented, there is a paucity of risk scoring tools during preconception. In the S-PRESTO cohort study, Asian women attempting to conceive, aged 18-45 years, were recruited. Multivariable logistic regression model coefficients were used to determine risk estimates for age, ethnicity, history of pregnancy loss, body mass index, smoking status, alcohol intake and dietary supplement intake; from these we derived a risk score ranging from 0 to 17. Miscarriage before 16 weeks of gestation, determined clinically or via ultrasound. Among 465 included women, 59 had miscarriages and 406 had pregnancy ≥ 16 weeks of gestation. Higher rates of miscarriage were observed at higher risk scores (5.3% at score ≤ 3, 17.0% at score 4–6, 40.0% at score 7–8 and 46.2% at score ≥ 9). Women with scores ≤ 3 were defined as low-risk level (< 10% miscarriage); scores 4–6 as intermediate-risk level (10% to < 40% miscarriage); scores ≥ 7 as high-risk level (≥ 40% miscarriage). The risk score yielded an area under the receiver-operating-characteristic curve of 0.74 (95% confidence interval 0.67, 0.81; p < 0.001). This novel scoring tool allows women to self-evaluate their miscarriage risk level, which facilitates lifestyle changes to optimize modifiable risk factors in the preconception period and reduces risk of spontaneous miscarriage. Nature Publishing Group UK 2021-06-08 /pmc/articles/PMC8187346/ /pubmed/34103654 http://dx.doi.org/10.1038/s41598-021-91567-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Choo, Xin Hui
Ku, Chee Wai
Cheung, Yin Bun
Godfrey, Keith M.
Chong, Yap-Seng
Shek, Lynette Pei-Chi
Tan, Kok Hian
Tan, Thiam Chye
Nadarajah, Sadhana
Yap, Fabian Kok Peng
Colega, Marjorelee T.
Chong, Mary Foong-Fong
Chan, Shiao-Yng
Loy, See Ling
Chan, Jerry Kok Yen
Risk score to stratify miscarriage risk levels in preconception women
title Risk score to stratify miscarriage risk levels in preconception women
title_full Risk score to stratify miscarriage risk levels in preconception women
title_fullStr Risk score to stratify miscarriage risk levels in preconception women
title_full_unstemmed Risk score to stratify miscarriage risk levels in preconception women
title_short Risk score to stratify miscarriage risk levels in preconception women
title_sort risk score to stratify miscarriage risk levels in preconception women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187346/
https://www.ncbi.nlm.nih.gov/pubmed/34103654
http://dx.doi.org/10.1038/s41598-021-91567-8
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