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Moderate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci

The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop resistance to 5-FC at a high frequency when exposed to concentrations several fold above the...

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Detalles Bibliográficos
Autores principales:	Chang, Yun C., Lamichhane, Ami Khanal, Cai, Hongyi, Walter, Peter J., Bennett, John E., Kwon-Chung, Kyung J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187385/ https://www.ncbi.nlm.nih.gov/pubmed/34103502 http://dx.doi.org/10.1038/s41467-021-23745-1

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