Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex

Partially unfolded alpha-lactalbumin forms the oleic acid complex HAMLET, with potent tumoricidal activity. Here we define a peptide-based molecular approach for targeting and killing tumor cells, and evidence of its clinical potential (ClinicalTrials.gov NCT03560479). A 39-residue alpha-helical pep...

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Detalles Bibliográficos
Autores principales: Brisuda, Antonín, Ho, James C. S., Kandiyal, Pancham S., Ng, Justin T-Y., Ambite, Ines, Butler, Daniel S. C., Háček, Jaromir, Wan, Murphy Lam Yim, Tran, Thi Hien, Nadeem, Aftab, Tran, Tuan Hiep, Hastings, Anna, Storm, Petter, Fortunati, Daniel L., Esmaeili, Parisa, Novotna, Hana, Horňák, Jakub, Mu, Y. G., Mok, K. H., Babjuk, Marek, Svanborg, Catharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187399/
https://www.ncbi.nlm.nih.gov/pubmed/34103518
http://dx.doi.org/10.1038/s41467-021-23748-y

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