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Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model

Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing cap...

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Autores principales: Wegener, Bernd, Behnke, Maik, Milz, Stefan, Jansson, Volkmar, Redlich, Christian, Hermanns, Walter, Birkenmaier, Christof, Pieper, Korbinian, Weißgärber, Thomas, Quadbeck, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187418/
https://www.ncbi.nlm.nih.gov/pubmed/34103567
http://dx.doi.org/10.1038/s41598-021-91296-y
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author Wegener, Bernd
Behnke, Maik
Milz, Stefan
Jansson, Volkmar
Redlich, Christian
Hermanns, Walter
Birkenmaier, Christof
Pieper, Korbinian
Weißgärber, Thomas
Quadbeck, Peter
author_facet Wegener, Bernd
Behnke, Maik
Milz, Stefan
Jansson, Volkmar
Redlich, Christian
Hermanns, Walter
Birkenmaier, Christof
Pieper, Korbinian
Weißgärber, Thomas
Quadbeck, Peter
author_sort Wegener, Bernd
collection PubMed
description Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated.
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spelling pubmed-81874182021-06-09 Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model Wegener, Bernd Behnke, Maik Milz, Stefan Jansson, Volkmar Redlich, Christian Hermanns, Walter Birkenmaier, Christof Pieper, Korbinian Weißgärber, Thomas Quadbeck, Peter Sci Rep Article Despite the high potential of healthy bone to regenerate, the reconstruction of large bone defects remains a challenge. Due to the lack of mechanical stability of existing bone substitutes, recently developed degradable metallic alloys are an interesting alternative providing higher load-bearing capabilities. Degradable iron-based alloys therefore might be an attractive innovation. To test the suitability of a newly-designed iron-based alloy for such applications, an animal experiment was performed. Porous iron-based degradable implants with two different densities and a control group were tested. The implants were positioned in the proximal tibia of Merino sheep. Over a period of 6 and 12 months, blood and histological parameters were monitored for signs of inflammation and degradation. In the histological evaluation of the implants` environment we found degraded alloy particles, but no inflammatory reaction. Iron particles were also found within the popliteal lymph nodes on both sides. The serum blood levels of phosphorus, iron and ferritin in the long term groups were elevated. Other parameters did not show any changes. Iron-based degradable porous bone replacement implants showed a good biocompatibility in this experiment. For a clinical application, however, the rate of degradation would have to be significantly increased. Biocompatibility would then have to be re-evaluated. Nature Publishing Group UK 2021-06-08 /pmc/articles/PMC8187418/ /pubmed/34103567 http://dx.doi.org/10.1038/s41598-021-91296-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Wegener, Bernd
Behnke, Maik
Milz, Stefan
Jansson, Volkmar
Redlich, Christian
Hermanns, Walter
Birkenmaier, Christof
Pieper, Korbinian
Weißgärber, Thomas
Quadbeck, Peter
Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_full Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_fullStr Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_full_unstemmed Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_short Local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
title_sort local and systemic inflammation after implantation of a novel iron based porous degradable bone replacement material in sheep model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187418/
https://www.ncbi.nlm.nih.gov/pubmed/34103567
http://dx.doi.org/10.1038/s41598-021-91296-y
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