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HIV-1 sequences in lentiviral vector genomes can be substantially reduced without compromising transduction efficiency

Many lentiviral vectors used for gene therapy are derived from HIV-1. An optimal vector genome would include only the viral sequences required for transduction efficiency and gene expression to minimize the amount of foreign sequence inserted into a patient’s genome. However, it remains unclear whet...

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Detalles Bibliográficos
Autores principales:	Sertkaya, Helin, Ficarelli, Mattia, Sweeney, Nathan P., Parker, Hannah, Vink, Conrad A., Swanson, Chad M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187449/ https://www.ncbi.nlm.nih.gov/pubmed/34103612 http://dx.doi.org/10.1038/s41598-021-91309-w

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