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Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study
BACKGROUND: This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187455/ https://www.ncbi.nlm.nih.gov/pubmed/34107888 http://dx.doi.org/10.1186/s12887-021-02734-9 |
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author | Warnock, A. Szatkowski, L. Lakshmanan, A. Lee, L. Kelsall, W. |
author_facet | Warnock, A. Szatkowski, L. Lakshmanan, A. Lee, L. Kelsall, W. |
author_sort | Warnock, A. |
collection | PubMed |
description | BACKGROUND: This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questionnaires for preterm neonates undergoing PDA ligation (PDAL) between 1st Sept 2012 – 30th Sept 2013. Infants born less than 37 weeks gestation, who underwent PDAL prior to discharge home, with no other structural cardiac abnormality, were included. Information collected included: patient demographics, pre and post-operative clinical characteristics, pre-operative medical management, post-operative complications and outcome. RESULTS: Over the study, 263 infants underwent PDAL an incidence of 3.07 per 10,000 live births. 88% were born extremely preterm (< 28 weeks) and 60% were male. The commonest reasons for ligation were inability to wean respiratory support (83.7%) and haemodynamically significant PDA (87.8%). Pre-operatively 65.7% received medical therapy. Surgery was performed at a median age of 33 days (range 9-260, IQR 24-48); the corrected age was less than 31 + 6 week in 50.6% babies at PDAL. Most, (90%), of procedures were open ligation; only 9 (3.4%) were catheter occlusions (PDACO). 20.5% of patients had post-operative complications. The 30-day mortality was 3%, with 93.5% surviving to hospital discharge. CONCLUSION: This study showed there was little consensus over medical and surgical management of the PDA or timing of surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-021-02734-9. |
format | Online Article Text |
id | pubmed-8187455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81874552021-06-09 Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study Warnock, A. Szatkowski, L. Lakshmanan, A. Lee, L. Kelsall, W. BMC Pediatr Research BACKGROUND: This study aimed to provide UK data describing the incidence of patent ductus arteriosus (PDA) surgery in the neonatal population, including: pre-ligation management, and outcomes until discharge. We used British Paediatric Surveillance Unit (BPSU) methodology; collecting data via questionnaires for preterm neonates undergoing PDA ligation (PDAL) between 1st Sept 2012 – 30th Sept 2013. Infants born less than 37 weeks gestation, who underwent PDAL prior to discharge home, with no other structural cardiac abnormality, were included. Information collected included: patient demographics, pre and post-operative clinical characteristics, pre-operative medical management, post-operative complications and outcome. RESULTS: Over the study, 263 infants underwent PDAL an incidence of 3.07 per 10,000 live births. 88% were born extremely preterm (< 28 weeks) and 60% were male. The commonest reasons for ligation were inability to wean respiratory support (83.7%) and haemodynamically significant PDA (87.8%). Pre-operatively 65.7% received medical therapy. Surgery was performed at a median age of 33 days (range 9-260, IQR 24-48); the corrected age was less than 31 + 6 week in 50.6% babies at PDAL. Most, (90%), of procedures were open ligation; only 9 (3.4%) were catheter occlusions (PDACO). 20.5% of patients had post-operative complications. The 30-day mortality was 3%, with 93.5% surviving to hospital discharge. CONCLUSION: This study showed there was little consensus over medical and surgical management of the PDA or timing of surgery. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-021-02734-9. BioMed Central 2021-06-09 /pmc/articles/PMC8187455/ /pubmed/34107888 http://dx.doi.org/10.1186/s12887-021-02734-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Warnock, A. Szatkowski, L. Lakshmanan, A. Lee, L. Kelsall, W. Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title | Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title_full | Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title_fullStr | Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title_full_unstemmed | Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title_short | Surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
title_sort | surgical management of patent ductus arteriosus in pre-term infants - a british paediatric surveillance study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187455/ https://www.ncbi.nlm.nih.gov/pubmed/34107888 http://dx.doi.org/10.1186/s12887-021-02734-9 |
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