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Maternal iron deficiency perturbs embryonic cardiovascular development in mice

Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen...

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Autores principales: Kalisch-Smith, Jacinta I., Ved, Nikita, Szumska, Dorota, Munro, Jacob, Troup, Michael, Harris, Shelley E., Rodriguez-Caro, Helena, Jacquemot, Aimée, Miller, Jack J., Stuart, Eleanor M., Wolna, Magda, Hardman, Emily, Prin, Fabrice, Lana-Elola, Eva, Aoidi, Rifdat, Fisher, Elizabeth M. C., Tybulewicz, Victor L. J., Mohun, Timothy J., Lakhal-Littleton, Samira, De Val, Sarah, Giannoulatou, Eleni, Sparrow, Duncan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187484/
https://www.ncbi.nlm.nih.gov/pubmed/34103494
http://dx.doi.org/10.1038/s41467-021-23660-5
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author Kalisch-Smith, Jacinta I.
Ved, Nikita
Szumska, Dorota
Munro, Jacob
Troup, Michael
Harris, Shelley E.
Rodriguez-Caro, Helena
Jacquemot, Aimée
Miller, Jack J.
Stuart, Eleanor M.
Wolna, Magda
Hardman, Emily
Prin, Fabrice
Lana-Elola, Eva
Aoidi, Rifdat
Fisher, Elizabeth M. C.
Tybulewicz, Victor L. J.
Mohun, Timothy J.
Lakhal-Littleton, Samira
De Val, Sarah
Giannoulatou, Eleni
Sparrow, Duncan B.
author_facet Kalisch-Smith, Jacinta I.
Ved, Nikita
Szumska, Dorota
Munro, Jacob
Troup, Michael
Harris, Shelley E.
Rodriguez-Caro, Helena
Jacquemot, Aimée
Miller, Jack J.
Stuart, Eleanor M.
Wolna, Magda
Hardman, Emily
Prin, Fabrice
Lana-Elola, Eva
Aoidi, Rifdat
Fisher, Elizabeth M. C.
Tybulewicz, Victor L. J.
Mohun, Timothy J.
Lakhal-Littleton, Samira
De Val, Sarah
Giannoulatou, Eleni
Sparrow, Duncan B.
author_sort Kalisch-Smith, Jacinta I.
collection PubMed
description Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene–environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women.
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spelling pubmed-81874842021-07-01 Maternal iron deficiency perturbs embryonic cardiovascular development in mice Kalisch-Smith, Jacinta I. Ved, Nikita Szumska, Dorota Munro, Jacob Troup, Michael Harris, Shelley E. Rodriguez-Caro, Helena Jacquemot, Aimée Miller, Jack J. Stuart, Eleanor M. Wolna, Magda Hardman, Emily Prin, Fabrice Lana-Elola, Eva Aoidi, Rifdat Fisher, Elizabeth M. C. Tybulewicz, Victor L. J. Mohun, Timothy J. Lakhal-Littleton, Samira De Val, Sarah Giannoulatou, Eleni Sparrow, Duncan B. Nat Commun Article Congenital heart disease (CHD) is the most common class of human birth defects, with a prevalence of 0.9% of births. However, two-thirds of cases have an unknown cause, and many of these are thought to be caused by in utero exposure to environmental teratogens. Here we identify a potential teratogen causing CHD in mice: maternal iron deficiency (ID). We show that maternal ID in mice causes severe cardiovascular defects in the offspring. These defects likely arise from increased retinoic acid signalling in ID embryos. The defects can be prevented by iron administration in early pregnancy. It has also been proposed that teratogen exposure may potentiate the effects of genetic predisposition to CHD through gene–environment interaction. Here we show that maternal ID increases the severity of heart and craniofacial defects in a mouse model of Down syndrome. It will be important to understand if the effects of maternal ID seen here in mice may have clinical implications for women. Nature Publishing Group UK 2021-06-08 /pmc/articles/PMC8187484/ /pubmed/34103494 http://dx.doi.org/10.1038/s41467-021-23660-5 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Kalisch-Smith, Jacinta I.
Ved, Nikita
Szumska, Dorota
Munro, Jacob
Troup, Michael
Harris, Shelley E.
Rodriguez-Caro, Helena
Jacquemot, Aimée
Miller, Jack J.
Stuart, Eleanor M.
Wolna, Magda
Hardman, Emily
Prin, Fabrice
Lana-Elola, Eva
Aoidi, Rifdat
Fisher, Elizabeth M. C.
Tybulewicz, Victor L. J.
Mohun, Timothy J.
Lakhal-Littleton, Samira
De Val, Sarah
Giannoulatou, Eleni
Sparrow, Duncan B.
Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title_full Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title_fullStr Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title_full_unstemmed Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title_short Maternal iron deficiency perturbs embryonic cardiovascular development in mice
title_sort maternal iron deficiency perturbs embryonic cardiovascular development in mice
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187484/
https://www.ncbi.nlm.nih.gov/pubmed/34103494
http://dx.doi.org/10.1038/s41467-021-23660-5
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