The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications

COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all show...

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Detalles Bibliográficos
Autores principales: Breikaa, Randa M., Lilly, Brenda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187573/
https://www.ncbi.nlm.nih.gov/pubmed/34124207
http://dx.doi.org/10.3389/fcvm.2021.681948
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author Breikaa, Randa M.
Lilly, Brenda
author_facet Breikaa, Randa M.
Lilly, Brenda
author_sort Breikaa, Randa M.
collection PubMed
description COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients.
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spelling pubmed-81875732021-06-10 The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications Breikaa, Randa M. Lilly, Brenda Front Cardiovasc Med Cardiovascular Medicine COVID-19 is associated with a large number of cardiovascular sequelae, including dysrhythmias, myocardial injury, myocarditis and thrombosis. The Notch pathway is one likely culprit leading to these complications due to its direct role in viral entry, inflammation and coagulation processes, all shown to be key parts of COVID-19 pathogenesis. This review highlights links between the pathophysiology of SARS-CoV2 and the Notch signaling pathway that serve as primary drivers of the cardiovascular complications seen in COVID-19 patients. Frontiers Media S.A. 2021-05-26 /pmc/articles/PMC8187573/ /pubmed/34124207 http://dx.doi.org/10.3389/fcvm.2021.681948 Text en Copyright © 2021 Breikaa and Lilly. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Breikaa, Randa M.
Lilly, Brenda
The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title_full The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title_fullStr The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title_full_unstemmed The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title_short The Notch Pathway: A Link Between COVID-19 Pathophysiology and Its Cardiovascular Complications
title_sort notch pathway: a link between covid-19 pathophysiology and its cardiovascular complications
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187573/
https://www.ncbi.nlm.nih.gov/pubmed/34124207
http://dx.doi.org/10.3389/fcvm.2021.681948
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