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Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity
To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatc...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187649/ https://www.ncbi.nlm.nih.gov/pubmed/34103511 http://dx.doi.org/10.1038/s41467-021-23802-9 |
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author | Park, Seongjun Yuk, Hyunwoo Zhao, Ruike Yim, Yeong Shin Woldeghebriel, Eyob W. Kang, Jeewoo Canales, Andres Fink, Yoel Choi, Gloria B. Zhao, Xuanhe Anikeeva, Polina |
author_facet | Park, Seongjun Yuk, Hyunwoo Zhao, Ruike Yim, Yeong Shin Woldeghebriel, Eyob W. Kang, Jeewoo Canales, Andres Fink, Yoel Choi, Gloria B. Zhao, Xuanhe Anikeeva, Polina |
author_sort | Park, Seongjun |
collection | PubMed |
description | To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatch between the probes and the neural tissues. To address this challenge, we developed a multifunctional sensing and actuation platform consisting of multimaterial fibers intimately integrated within a soft hydrogel matrix mimicking the brain tissue. These hybrid devices possess adaptive bending stiffness determined by the hydration states of the hydrogel matrix. This enables their direct insertion into the deep brain regions, while minimizing tissue damage associated with the brain micromotion after implantation. The hydrogel hybrid devices permit electrophysiological, optogenetic, and behavioral studies of neural circuits with minimal foreign body responses and tracking of stable isolated single neuron potentials in freely moving mice over 6 months following implantation. |
format | Online Article Text |
id | pubmed-8187649 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81876492021-07-01 Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity Park, Seongjun Yuk, Hyunwoo Zhao, Ruike Yim, Yeong Shin Woldeghebriel, Eyob W. Kang, Jeewoo Canales, Andres Fink, Yoel Choi, Gloria B. Zhao, Xuanhe Anikeeva, Polina Nat Commun Article To understand the underlying mechanisms of progressive neurophysiological phenomena, neural interfaces should interact bi-directionally with brain circuits over extended periods of time. However, such interfaces remain limited by the foreign body response that stems from the chemo-mechanical mismatch between the probes and the neural tissues. To address this challenge, we developed a multifunctional sensing and actuation platform consisting of multimaterial fibers intimately integrated within a soft hydrogel matrix mimicking the brain tissue. These hybrid devices possess adaptive bending stiffness determined by the hydration states of the hydrogel matrix. This enables their direct insertion into the deep brain regions, while minimizing tissue damage associated with the brain micromotion after implantation. The hydrogel hybrid devices permit electrophysiological, optogenetic, and behavioral studies of neural circuits with minimal foreign body responses and tracking of stable isolated single neuron potentials in freely moving mice over 6 months following implantation. Nature Publishing Group UK 2021-06-08 /pmc/articles/PMC8187649/ /pubmed/34103511 http://dx.doi.org/10.1038/s41467-021-23802-9 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Park, Seongjun Yuk, Hyunwoo Zhao, Ruike Yim, Yeong Shin Woldeghebriel, Eyob W. Kang, Jeewoo Canales, Andres Fink, Yoel Choi, Gloria B. Zhao, Xuanhe Anikeeva, Polina Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title | Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title_full | Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title_fullStr | Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title_full_unstemmed | Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title_short | Adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
title_sort | adaptive and multifunctional hydrogel hybrid probes for long-term sensing and modulation of neural activity |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187649/ https://www.ncbi.nlm.nih.gov/pubmed/34103511 http://dx.doi.org/10.1038/s41467-021-23802-9 |
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