Oncogenic BRAF, unrestrained by TGFβ-receptor signalling, drives right-sided colonic tumorigenesis

Right-sided (proximal) colorectal cancer (CRC) has a poor prognosis and a distinct mutational profile, characterized by oncogenic BRAF mutations and aberrations in mismatch repair and TGFβ signalling. Here, we describe a mouse model of right-sided colon cancer driven by oncogenic BRAF and loss of ep...

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Detalles Bibliográficos
Autores principales: Leach, Joshua D. G., Vlahov, Nikola, Tsantoulis, Petros, Ridgway, Rachel A., Flanagan, Dustin J., Gilroy, Kathryn, Sphyris, Nathalie, Vázquez, Ester G., Vincent, David F., Faller, William J., Hodder, Michael C., Raven, Alexander, Fey, Sigrid, Najumudeen, Arafath K., Strathdee, Douglas, Nixon, Colin, Hughes, Mark, Clark, William, Shaw, Robin, van Hooff, Sander R., Huels, David J., Medema, Jan Paul, Barry, Simon T., Frame, Margaret C., Unciti-Broceta, Asier, Leedham, Simon J., Inman, Gareth J., Jackstadt, Rene, Thompson, Barry J., Campbell, Andrew D., Tejpar, Sabine, Sansom, Owen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187652/
https://www.ncbi.nlm.nih.gov/pubmed/34103493
http://dx.doi.org/10.1038/s41467-021-23717-5

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