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Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study

Resting state functional magnetic resonance imaging studies of nocturnal enuresis have focused primarily on regional metrics in the blood oxygen level dependent (BOLD) signal ranging from 0.01 to 0.08 Hz. However, it remains unclear how local metrics show in sub-frequency band. 129 children with noc...

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Autores principales: Zheng, Xiangyu, Sun, Jiawei, Lv, Yating, Wang, Mengxing, Du, Xiaoxia, Jia, Xize, Ma, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187680/
https://www.ncbi.nlm.nih.gov/pubmed/34103549
http://dx.doi.org/10.1038/s41598-021-90546-3
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author Zheng, Xiangyu
Sun, Jiawei
Lv, Yating
Wang, Mengxing
Du, Xiaoxia
Jia, Xize
Ma, Jun
author_facet Zheng, Xiangyu
Sun, Jiawei
Lv, Yating
Wang, Mengxing
Du, Xiaoxia
Jia, Xize
Ma, Jun
author_sort Zheng, Xiangyu
collection PubMed
description Resting state functional magnetic resonance imaging studies of nocturnal enuresis have focused primarily on regional metrics in the blood oxygen level dependent (BOLD) signal ranging from 0.01 to 0.08 Hz. However, it remains unclear how local metrics show in sub-frequency band. 129 children with nocturnal enuresis (NE) and 37 healthy controls were included in this study. The patients were diagnosed by the pediatricians in Shanghai Children’s Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, according to the criteria from International Children's Continence Society (ICCS). Questionnaires were used to evaluate the symptoms of enuresis and completed by the participants. In this study, fALFF, ReHo and PerAF were calculated within five different frequency bands: typical band (0.01–0.08 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz). In the typical band, ReHo increased in the left insula and the right thalamus, while fALFF decreased in the right insula in children with NE. Besides, PerAF was increased in the right middle temporal gyrus in these children. The results regarding ReHo, fALFF and PerAF in the typical band was similar to those in slow-5 band, respectively. A correlation was found between the PerAF value of the right middle temporal gyrus and scores of the urinary intention-related wakefulness. Results in other bands were either negative or in white matter. NE children might have abnormal intrinsic neural oscillations mainly on slow-5 bands.
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spelling pubmed-81876802021-06-09 Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study Zheng, Xiangyu Sun, Jiawei Lv, Yating Wang, Mengxing Du, Xiaoxia Jia, Xize Ma, Jun Sci Rep Article Resting state functional magnetic resonance imaging studies of nocturnal enuresis have focused primarily on regional metrics in the blood oxygen level dependent (BOLD) signal ranging from 0.01 to 0.08 Hz. However, it remains unclear how local metrics show in sub-frequency band. 129 children with nocturnal enuresis (NE) and 37 healthy controls were included in this study. The patients were diagnosed by the pediatricians in Shanghai Children’s Medical Center affiliated to Shanghai Jiao Tong University School of Medicine, according to the criteria from International Children's Continence Society (ICCS). Questionnaires were used to evaluate the symptoms of enuresis and completed by the participants. In this study, fALFF, ReHo and PerAF were calculated within five different frequency bands: typical band (0.01–0.08 Hz), slow-5 (0.01–0.027 Hz), slow-4 (0.027–0.073 Hz), slow-3 (0.073–0.198 Hz), and slow-2 (0.198–0.25 Hz). In the typical band, ReHo increased in the left insula and the right thalamus, while fALFF decreased in the right insula in children with NE. Besides, PerAF was increased in the right middle temporal gyrus in these children. The results regarding ReHo, fALFF and PerAF in the typical band was similar to those in slow-5 band, respectively. A correlation was found between the PerAF value of the right middle temporal gyrus and scores of the urinary intention-related wakefulness. Results in other bands were either negative or in white matter. NE children might have abnormal intrinsic neural oscillations mainly on slow-5 bands. Nature Publishing Group UK 2021-06-08 /pmc/articles/PMC8187680/ /pubmed/34103549 http://dx.doi.org/10.1038/s41598-021-90546-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Zheng, Xiangyu
Sun, Jiawei
Lv, Yating
Wang, Mengxing
Du, Xiaoxia
Jia, Xize
Ma, Jun
Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title_full Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title_fullStr Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title_full_unstemmed Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title_short Frequency-specific alterations of the resting-state BOLD signals in nocturnal enuresis: an fMRI Study
title_sort frequency-specific alterations of the resting-state bold signals in nocturnal enuresis: an fmri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187680/
https://www.ncbi.nlm.nih.gov/pubmed/34103549
http://dx.doi.org/10.1038/s41598-021-90546-3
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