Effect of metformin versus placebo on metabolic factors in the MA.32 randomized breast cancer trial

Metformin may exert anticancer effects through indirect (mediated by metabolic changes) or direct mechanisms. The goal was to examine metformin impact on metabolic factors in non-diabetic subjects and determine whether this impact varies by baseline BMI, insulin, and rs11212617 SNP in CCTG MA.32, a...

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Detalles Bibliográficos
Autores principales: Goodwin, Pamela J., Dowling, Ryan J. O., Ennis, Marguerite, Chen, Bingshu E., Parulekar, Wendy R., Shepherd, Lois E., Burnell, Margot J., Vander Meer, Rachel, Molckovsky, Andrea, Gurjal, Anagha, Gelmon, Karen A., Ligibel, Jennifer A., Hershman, Dawn L., Mayer, Ingrid A., Whelan, Timothy J., Hobday, Timothy J., Rastogi, Priya, Rabaglio-Poretti, Manuela, Lemieux, Julie, Thompson, Alastair M., Rea, Daniel W., Stambolic, Vuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187713/
https://www.ncbi.nlm.nih.gov/pubmed/34103538
http://dx.doi.org/10.1038/s41523-021-00275-z

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