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Extracellular mutation induces an allosteric effect across the membrane and hampers the activity of MRP1 (ABCC1)

Dynamic conformational changes play a major role in the function of proteins, including the ATP-Binding Cassette (ABC) transporters. Multidrug Resistance Protein 1 (MRP1) is an ABC exporter that protects cells from toxic molecules. Overexpression of MRP1 has been shown to confer Multidrug Resistance...

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Detalles Bibliográficos
Autores principales:	Bin Kanner, Yuval, Ganoth, Assaf, Tsfadia, Yossi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187718/ https://www.ncbi.nlm.nih.gov/pubmed/34103599 http://dx.doi.org/10.1038/s41598-021-91461-3

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