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The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin
Accurate recurrence risk assessment in hormone receptor positive, HER2/neu negative breast cancer is critical to plan precise therapy. CanAssist Breast (CAB) assesses recurrence risk based on tumor biology using artificial intelligence-based approach. We report CAB risk assessment correlating with d...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187842/ https://www.ncbi.nlm.nih.gov/pubmed/34098459 http://dx.doi.org/10.1016/j.breast.2021.05.007 |
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author | Chandra Doval, Dinesh Mehta, Anurag Somashekhar, S.P. Gunda, Aparna Singh, Gurpreet Bal, Amanjit Khare, Siddhant Prakash V Serkad, Chandra Adinarayan, Manjula Krishnamoorthy, Naveen Vijay, Devanhalli Govinda Anantakrishnan, Radha Bhattacharyya, G.S. Bakre, Manjiri M. |
author_facet | Chandra Doval, Dinesh Mehta, Anurag Somashekhar, S.P. Gunda, Aparna Singh, Gurpreet Bal, Amanjit Khare, Siddhant Prakash V Serkad, Chandra Adinarayan, Manjula Krishnamoorthy, Naveen Vijay, Devanhalli Govinda Anantakrishnan, Radha Bhattacharyya, G.S. Bakre, Manjiri M. |
author_sort | Chandra Doval, Dinesh |
collection | PubMed |
description | Accurate recurrence risk assessment in hormone receptor positive, HER2/neu negative breast cancer is critical to plan precise therapy. CanAssist Breast (CAB) assesses recurrence risk based on tumor biology using artificial intelligence-based approach. We report CAB risk assessment correlating with disease outcomes in multiple clinically high- and low-risk subgroups. In this retrospective cohort of 925 patients [median age-54 (22–86)] CAB had hazard ratio (HR) of 3 (1.83–5.21) and 2.5 (1.45–4.29), P = 0.0009) in univariate and multivariate analysis. CAB's HR in sub-groups with the other determinants of outcome, T2 (HR: 2.79 (1.49–5.25), P = 0.0001); age [< 50 (HR: 3.14 (1.39–7), P = 0.0008)]. Besides application in node-negative patients, CAB's HR was 2.45 (1.34–4.47), P = 0.0023) in node-positive patients. In clinically low-risk patients (N0 tumors up to 5 cms) (HR: 2.48 (0.79–7.8), P = 0.03) and with luminal-A characteristics (HR: 4.54 (1–19.75), P = 0.004), CAB identified >16% as high-risk with recurrence rates of up to 12%. In clinically high-risk patients (T2N1 tumors (HR: 2.65 (1.31–5.36), P = 0.003; low-risk DMFS: 92.66 ± 1.88) and in women with luminal-B characteristics (HR: 3.24; (1.69–6.22), P < 0.0001; low-risk DMFS: 93.34 ± 1.34)), CAB identified >64% as low-risk. Thus, CAB prognostication was significant in women with clinically low- and high-risk disease. The data imply the use of CAB for providing helpful information to stratify tumors based on biology incorporated with clinical features for Indian patients, which can be extrapolated to regions with similarly characterized patients, South-East Asia. |
format | Online Article Text |
id | pubmed-8187842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-81878422021-06-16 The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin Chandra Doval, Dinesh Mehta, Anurag Somashekhar, S.P. Gunda, Aparna Singh, Gurpreet Bal, Amanjit Khare, Siddhant Prakash V Serkad, Chandra Adinarayan, Manjula Krishnamoorthy, Naveen Vijay, Devanhalli Govinda Anantakrishnan, Radha Bhattacharyya, G.S. Bakre, Manjiri M. Breast Original Article Accurate recurrence risk assessment in hormone receptor positive, HER2/neu negative breast cancer is critical to plan precise therapy. CanAssist Breast (CAB) assesses recurrence risk based on tumor biology using artificial intelligence-based approach. We report CAB risk assessment correlating with disease outcomes in multiple clinically high- and low-risk subgroups. In this retrospective cohort of 925 patients [median age-54 (22–86)] CAB had hazard ratio (HR) of 3 (1.83–5.21) and 2.5 (1.45–4.29), P = 0.0009) in univariate and multivariate analysis. CAB's HR in sub-groups with the other determinants of outcome, T2 (HR: 2.79 (1.49–5.25), P = 0.0001); age [< 50 (HR: 3.14 (1.39–7), P = 0.0008)]. Besides application in node-negative patients, CAB's HR was 2.45 (1.34–4.47), P = 0.0023) in node-positive patients. In clinically low-risk patients (N0 tumors up to 5 cms) (HR: 2.48 (0.79–7.8), P = 0.03) and with luminal-A characteristics (HR: 4.54 (1–19.75), P = 0.004), CAB identified >16% as high-risk with recurrence rates of up to 12%. In clinically high-risk patients (T2N1 tumors (HR: 2.65 (1.31–5.36), P = 0.003; low-risk DMFS: 92.66 ± 1.88) and in women with luminal-B characteristics (HR: 3.24; (1.69–6.22), P < 0.0001; low-risk DMFS: 93.34 ± 1.34)), CAB identified >64% as low-risk. Thus, CAB prognostication was significant in women with clinically low- and high-risk disease. The data imply the use of CAB for providing helpful information to stratify tumors based on biology incorporated with clinical features for Indian patients, which can be extrapolated to regions with similarly characterized patients, South-East Asia. Elsevier 2021-05-28 /pmc/articles/PMC8187842/ /pubmed/34098459 http://dx.doi.org/10.1016/j.breast.2021.05.007 Text en © 2021 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Chandra Doval, Dinesh Mehta, Anurag Somashekhar, S.P. Gunda, Aparna Singh, Gurpreet Bal, Amanjit Khare, Siddhant Prakash V Serkad, Chandra Adinarayan, Manjula Krishnamoorthy, Naveen Vijay, Devanhalli Govinda Anantakrishnan, Radha Bhattacharyya, G.S. Bakre, Manjiri M. The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title | The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title_full | The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title_fullStr | The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title_full_unstemmed | The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title_short | The usefulness of CanAssist breast in the assessment of recurrence risk in patients of ethnic Indian origin |
title_sort | usefulness of canassist breast in the assessment of recurrence risk in patients of ethnic indian origin |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187842/ https://www.ncbi.nlm.nih.gov/pubmed/34098459 http://dx.doi.org/10.1016/j.breast.2021.05.007 |
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