Lung Transplantation and the Era of the Sensitized Patient

Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, “sensitiz...

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Autores principales: Young, Katherine A., Ali, Hakim A., Beermann, Kristi J., Reynolds, John M., Snyder, Laurie D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187850/
https://www.ncbi.nlm.nih.gov/pubmed/34122454
http://dx.doi.org/10.3389/fimmu.2021.689420
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author Young, Katherine A.
Ali, Hakim A.
Beermann, Kristi J.
Reynolds, John M.
Snyder, Laurie D.
author_facet Young, Katherine A.
Ali, Hakim A.
Beermann, Kristi J.
Reynolds, John M.
Snyder, Laurie D.
author_sort Young, Katherine A.
collection PubMed
description Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, “sensitized patients” may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies.
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spelling pubmed-81878502021-06-10 Lung Transplantation and the Era of the Sensitized Patient Young, Katherine A. Ali, Hakim A. Beermann, Kristi J. Reynolds, John M. Snyder, Laurie D. Front Immunol Immunology Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibodies in lung transplant candidates, “sensitized patients” may predispose patients to AMR, CLAD, and higher mortality after transplant. This review will discuss issues surrounding the sensitized patient, including mechanisms of sensitization, implications within lung transplant, and management strategies. Frontiers Media S.A. 2021-05-26 /pmc/articles/PMC8187850/ /pubmed/34122454 http://dx.doi.org/10.3389/fimmu.2021.689420 Text en Copyright © 2021 Young, Ali, Beermann, Reynolds and Snyder https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Young, Katherine A.
Ali, Hakim A.
Beermann, Kristi J.
Reynolds, John M.
Snyder, Laurie D.
Lung Transplantation and the Era of the Sensitized Patient
title Lung Transplantation and the Era of the Sensitized Patient
title_full Lung Transplantation and the Era of the Sensitized Patient
title_fullStr Lung Transplantation and the Era of the Sensitized Patient
title_full_unstemmed Lung Transplantation and the Era of the Sensitized Patient
title_short Lung Transplantation and the Era of the Sensitized Patient
title_sort lung transplantation and the era of the sensitized patient
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187850/
https://www.ncbi.nlm.nih.gov/pubmed/34122454
http://dx.doi.org/10.3389/fimmu.2021.689420
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