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Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study

OBJECTIVE: Atypical meningioma is a non-benign tumor, and its prognostic factors and treatment strategies are unclear. METHODS: Patients with atypical meningioma, between 2004 and 2016, were collected from the Surveillance, Epidemiology, and End Results database. Then, we randomly divided patients i...

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Autores principales: Zhang, Gui-Jun, Liu, Xiao-Yin, You, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187879/
https://www.ncbi.nlm.nih.gov/pubmed/34123845
http://dx.doi.org/10.3389/fonc.2021.676683
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author Zhang, Gui-Jun
Liu, Xiao-Yin
You, Chao
author_facet Zhang, Gui-Jun
Liu, Xiao-Yin
You, Chao
author_sort Zhang, Gui-Jun
collection PubMed
description OBJECTIVE: Atypical meningioma is a non-benign tumor, and its prognostic factors and treatment strategies are unclear. METHODS: Patients with atypical meningioma, between 2004 and 2016, were collected from the Surveillance, Epidemiology, and End Results database. Then, we randomly divided patients into a training set and a validation set at a ratio of 8:2. The nomogram was constructed based on the multivariate Cox regression analyses. And the concordance index, calibration curves, and receiver operating character were used to assess the predictive ability of the nomogram. We divided the patient scores into three groups and constructed a survival curve using Kaplan–Meier analysis. RESULTS: After our inclusion and exclusion criteria, 2358 patients were histologically diagnosed of atypical meningioma. The prognostic nomogram comprised factors of overall survival, including age, tumor size and surgery. The concordance index was 0.715 (95%CI=0.688-0.742) for overall survival in the training set and 0.688 (95%CI=0.629-0.747) for overall survival in the validation set. The calibration curves and receiver operating character also indicated the good predictability of the nomogram. Risk stratification revealed a statistically significant difference among the three groups of patients according to quartiles of risk score. CONCLUSION: Gross total resection is an independent factor for survival, and radiation after non-gross total resection potentially confers a survival advantage for patients with atypical meningioma.
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spelling pubmed-81878792021-06-10 Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study Zhang, Gui-Jun Liu, Xiao-Yin You, Chao Front Oncol Oncology OBJECTIVE: Atypical meningioma is a non-benign tumor, and its prognostic factors and treatment strategies are unclear. METHODS: Patients with atypical meningioma, between 2004 and 2016, were collected from the Surveillance, Epidemiology, and End Results database. Then, we randomly divided patients into a training set and a validation set at a ratio of 8:2. The nomogram was constructed based on the multivariate Cox regression analyses. And the concordance index, calibration curves, and receiver operating character were used to assess the predictive ability of the nomogram. We divided the patient scores into three groups and constructed a survival curve using Kaplan–Meier analysis. RESULTS: After our inclusion and exclusion criteria, 2358 patients were histologically diagnosed of atypical meningioma. The prognostic nomogram comprised factors of overall survival, including age, tumor size and surgery. The concordance index was 0.715 (95%CI=0.688-0.742) for overall survival in the training set and 0.688 (95%CI=0.629-0.747) for overall survival in the validation set. The calibration curves and receiver operating character also indicated the good predictability of the nomogram. Risk stratification revealed a statistically significant difference among the three groups of patients according to quartiles of risk score. CONCLUSION: Gross total resection is an independent factor for survival, and radiation after non-gross total resection potentially confers a survival advantage for patients with atypical meningioma. Frontiers Media S.A. 2021-05-26 /pmc/articles/PMC8187879/ /pubmed/34123845 http://dx.doi.org/10.3389/fonc.2021.676683 Text en Copyright © 2021 Zhang, Liu and You https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Zhang, Gui-Jun
Liu, Xiao-Yin
You, Chao
Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title_full Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title_fullStr Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title_full_unstemmed Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title_short Clinical Factors and Outcomes of Atypical Meningioma: A Population-Based Study
title_sort clinical factors and outcomes of atypical meningioma: a population-based study
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187879/
https://www.ncbi.nlm.nih.gov/pubmed/34123845
http://dx.doi.org/10.3389/fonc.2021.676683
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