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Weekly methotrexate may reduce valproate levels causing relapse of genetic generalized epilepsy

• Seizures have been observed in epilepsy patients receiving high dose intravenous or intrathecal Methotrexate (Mtx) therapy for the treatment of leukemias, due to reduction in valproic acid (VPA) levels. • Prolonged low dose weekly Mtx exposure can also produce reduction in VPA levels causing seizu...

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Detalles Bibliográficos
Autores principales:	Cherian, Ajith, Shetty, Sharath Chandra, Divya, K.P., Pavuluri, Harini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187960/ https://www.ncbi.nlm.nih.gov/pubmed/34142078 http://dx.doi.org/10.1016/j.ebr.2021.100457

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