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Geranylgeraniol prevents zoledronic acid-mediated reduction of viable mesenchymal stem cells via induction of Rho-dependent YAP activation

Long-term use of zoledronic acid (ZA) increases the risk of medication-related osteonecrosis of the jaw (MRONJ). This may be attributed to ZA-mediated reduction of viable mesenchymal stem cells (MSCs). ZA inhibits protein geranylgeranylation, thus suppressing cell viability and proliferation. Gerany...

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Detalles Bibliográficos
Autores principales:	Singhatanadgit, Weerachai, Hankamolsiri, Weerawan, Janvikul, Wanida
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2021
Materias:	Biochemistry, Cellular and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187992/ https://www.ncbi.nlm.nih.gov/pubmed/34113452 http://dx.doi.org/10.1098/rsos.202066

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