Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis

Tocilizumab (TCZ), a biologic that blocks the signal transduction of interleukin-6, has been used for the treatment of various autoimmune diseases. Many of these cases are sometimes complicated by ulcerative colitis (UC). However, the effect of TCZ on UC is unclear. We experienced two cases with con...

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Autores principales: Hanioka, Yusuke, Shimizu, Katsushu, Yamagami, Keiko, Yao, Shuhei, Nakamura, Ryota, Nakamura, Tomoyuki, Goto, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188011/
https://www.ncbi.nlm.nih.gov/pubmed/33281154
http://dx.doi.org/10.2169/internalmedicine.5215-20
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author Hanioka, Yusuke
Shimizu, Katsushu
Yamagami, Keiko
Yao, Shuhei
Nakamura, Ryota
Nakamura, Tomoyuki
Goto, Hitoshi
author_facet Hanioka, Yusuke
Shimizu, Katsushu
Yamagami, Keiko
Yao, Shuhei
Nakamura, Ryota
Nakamura, Tomoyuki
Goto, Hitoshi
author_sort Hanioka, Yusuke
collection PubMed
description Tocilizumab (TCZ), a biologic that blocks the signal transduction of interleukin-6, has been used for the treatment of various autoimmune diseases. Many of these cases are sometimes complicated by ulcerative colitis (UC). However, the effect of TCZ on UC is unclear. We experienced two cases with concomitant UC that were treated with TCZ, one for Takayasu arteritis (TAK) and the other for relapsing polychondritis (RP). TCZ did not improve UC in either of these cases. TCZ might have adverse effects on the intestinal tract, since interleukin-6 signaling plays an important role in intestinal epithelium maintenance. Treatment with TCZ should therefore be carefully provided in patients complicated with UC.
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spelling pubmed-81880112021-06-16 Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis Hanioka, Yusuke Shimizu, Katsushu Yamagami, Keiko Yao, Shuhei Nakamura, Ryota Nakamura, Tomoyuki Goto, Hitoshi Intern Med Case Report Tocilizumab (TCZ), a biologic that blocks the signal transduction of interleukin-6, has been used for the treatment of various autoimmune diseases. Many of these cases are sometimes complicated by ulcerative colitis (UC). However, the effect of TCZ on UC is unclear. We experienced two cases with concomitant UC that were treated with TCZ, one for Takayasu arteritis (TAK) and the other for relapsing polychondritis (RP). TCZ did not improve UC in either of these cases. TCZ might have adverse effects on the intestinal tract, since interleukin-6 signaling plays an important role in intestinal epithelium maintenance. Treatment with TCZ should therefore be carefully provided in patients complicated with UC. The Japanese Society of Internal Medicine 2020-12-07 2021-05-15 /pmc/articles/PMC8188011/ /pubmed/33281154 http://dx.doi.org/10.2169/internalmedicine.5215-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Hanioka, Yusuke
Shimizu, Katsushu
Yamagami, Keiko
Yao, Shuhei
Nakamura, Ryota
Nakamura, Tomoyuki
Goto, Hitoshi
Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title_full Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title_fullStr Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title_full_unstemmed Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title_short Exacerbation of Ulcerative Colitis with Tocilizumab: A Report of Two Cases, One with Takayasu Arteritis and the Other with Relapsing Polychondritis
title_sort exacerbation of ulcerative colitis with tocilizumab: a report of two cases, one with takayasu arteritis and the other with relapsing polychondritis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188011/
https://www.ncbi.nlm.nih.gov/pubmed/33281154
http://dx.doi.org/10.2169/internalmedicine.5215-20
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