Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy

A 79-year-old man with lymphoma who tested negative for anti-hepatitis C virus (HCV) antibody received rituximab-containing chemotherapy. Liver dysfunction of unknown cause had persisted since the second cycle of chemotherapy. Ten months after treatment, he rapidly developed massive ascites and atro...

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Autores principales: Miyashita, Kaname, Hongo, Yui, Nakashima, Akihiko, Kato, Seiya, Kusano, Hironori, Morizono, Shusuke, Higashi, Nobuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188017/
https://www.ncbi.nlm.nih.gov/pubmed/33191319
http://dx.doi.org/10.2169/internalmedicine.4768-20
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author Miyashita, Kaname
Hongo, Yui
Nakashima, Akihiko
Kato, Seiya
Kusano, Hironori
Morizono, Shusuke
Higashi, Nobuhiko
author_facet Miyashita, Kaname
Hongo, Yui
Nakashima, Akihiko
Kato, Seiya
Kusano, Hironori
Morizono, Shusuke
Higashi, Nobuhiko
author_sort Miyashita, Kaname
collection PubMed
description A 79-year-old man with lymphoma who tested negative for anti-hepatitis C virus (HCV) antibody received rituximab-containing chemotherapy. Liver dysfunction of unknown cause had persisted since the second cycle of chemotherapy. Ten months after treatment, he rapidly developed massive ascites and atrophy of the liver, and we detected HCV RNA in his serum using real time polymerase chain reaction. Furthermore, medical interviews showed that the patient had no episodes for acute HCV infection, but he did have a history of unspecified liver dysfunction. These findings support the possibility of the reactivation of seronegative occult HCV infection due to chemotherapy in a cancer patient.
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spelling pubmed-81880172021-06-16 Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy Miyashita, Kaname Hongo, Yui Nakashima, Akihiko Kato, Seiya Kusano, Hironori Morizono, Shusuke Higashi, Nobuhiko Intern Med Case Report A 79-year-old man with lymphoma who tested negative for anti-hepatitis C virus (HCV) antibody received rituximab-containing chemotherapy. Liver dysfunction of unknown cause had persisted since the second cycle of chemotherapy. Ten months after treatment, he rapidly developed massive ascites and atrophy of the liver, and we detected HCV RNA in his serum using real time polymerase chain reaction. Furthermore, medical interviews showed that the patient had no episodes for acute HCV infection, but he did have a history of unspecified liver dysfunction. These findings support the possibility of the reactivation of seronegative occult HCV infection due to chemotherapy in a cancer patient. The Japanese Society of Internal Medicine 2020-11-16 2021-05-15 /pmc/articles/PMC8188017/ /pubmed/33191319 http://dx.doi.org/10.2169/internalmedicine.4768-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Miyashita, Kaname
Hongo, Yui
Nakashima, Akihiko
Kato, Seiya
Kusano, Hironori
Morizono, Shusuke
Higashi, Nobuhiko
Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title_full Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title_fullStr Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title_full_unstemmed Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title_short Fatal Hepatitis C after Chemotherapy in a Patient with Malignant Lymphoma: Possible Reactivation of Seronegative Occult Hepatitis C Virus Infection Due to Chemotherapy
title_sort fatal hepatitis c after chemotherapy in a patient with malignant lymphoma: possible reactivation of seronegative occult hepatitis c virus infection due to chemotherapy
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188017/
https://www.ncbi.nlm.nih.gov/pubmed/33191319
http://dx.doi.org/10.2169/internalmedicine.4768-20
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