Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies

A 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX...

Descripción completa

Detalles Bibliográficos
Autores principales: Wada, Shinichi, Kamei, Mayu, Uehara, Naoko, Tsuzaki, Koji, Hamano, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188018/
https://www.ncbi.nlm.nih.gov/pubmed/33328403
http://dx.doi.org/10.2169/internalmedicine.5934-20
_version_ 1783705256148860928
author Wada, Shinichi
Kamei, Mayu
Uehara, Naoko
Tsuzaki, Koji
Hamano, Toshiaki
author_facet Wada, Shinichi
Kamei, Mayu
Uehara, Naoko
Tsuzaki, Koji
Hamano, Toshiaki
author_sort Wada, Shinichi
collection PubMed
description A 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX-1 antibodies. He was diagnosed with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS). He died from aspiration pneumonia on day 9. Small-cell lung carcinoma (SCLC), which had not been obvious on computed tomography, was found during the autopsy. Patients with PCD-LEMS who test positive for SOX-1 antibodies should be carefully evaluated for SCLC.
format Online
Article
Text
id pubmed-8188018
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher The Japanese Society of Internal Medicine
record_format MEDLINE/PubMed
spelling pubmed-81880182021-06-16 Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies Wada, Shinichi Kamei, Mayu Uehara, Naoko Tsuzaki, Koji Hamano, Toshiaki Intern Med Case Report A 69-year-old man was admitted to our hospital for progressive muscle weakness in both lower limbs and limb ataxia (day 0). Nerve conduction studies showed low compound muscle action potential amplitudes at rest and increased amplitudes after maximum voluntary contraction. Blood testing revealed SOX-1 antibodies. He was diagnosed with paraneoplastic cerebellar degeneration and Lambert-Eaton myasthenic syndrome (PCD-LEMS). He died from aspiration pneumonia on day 9. Small-cell lung carcinoma (SCLC), which had not been obvious on computed tomography, was found during the autopsy. Patients with PCD-LEMS who test positive for SOX-1 antibodies should be carefully evaluated for SCLC. The Japanese Society of Internal Medicine 2020-12-15 2021-05-15 /pmc/articles/PMC8188018/ /pubmed/33328403 http://dx.doi.org/10.2169/internalmedicine.5934-20 Text en Copyright © 2021 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Wada, Shinichi
Kamei, Mayu
Uehara, Naoko
Tsuzaki, Koji
Hamano, Toshiaki
Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title_full Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title_fullStr Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title_full_unstemmed Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title_short Paraneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies
title_sort paraneoplastic cerebellar degeneration and lambert-eaton myasthenic syndrome with sox-1 antibodies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188018/
https://www.ncbi.nlm.nih.gov/pubmed/33328403
http://dx.doi.org/10.2169/internalmedicine.5934-20
work_keys_str_mv AT wadashinichi paraneoplasticcerebellardegenerationandlamberteatonmyasthenicsyndromewithsox1antibodies
AT kameimayu paraneoplasticcerebellardegenerationandlamberteatonmyasthenicsyndromewithsox1antibodies
AT ueharanaoko paraneoplasticcerebellardegenerationandlamberteatonmyasthenicsyndromewithsox1antibodies
AT tsuzakikoji paraneoplasticcerebellardegenerationandlamberteatonmyasthenicsyndromewithsox1antibodies
AT hamanotoshiaki paraneoplasticcerebellardegenerationandlamberteatonmyasthenicsyndromewithsox1antibodies

Ejemplares similares