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Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city

BACKGROUND: Dengue fever has been one of the most common mosquito-transmitted diseases in the world, affecting more than 128 countries in both tropical and subtropical regions. Bangladesh has been sufferring from dengue outbreaks almost annually since 2000, and in 2019, Bangladesh faced the worst ou...

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Autores principales: Mahmood, Rudbar, Benzadid, Md. Shadly, Weston, Sophie, Hossain, Ahmed, Ahmed, Tanveer, Mitra, Dipak Kumar, Ahmed, Shakil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188050/
https://www.ncbi.nlm.nih.gov/pubmed/34141938
http://dx.doi.org/10.1016/j.heliyon.2021.e07183
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author Mahmood, Rudbar
Benzadid, Md. Shadly
Weston, Sophie
Hossain, Ahmed
Ahmed, Tanveer
Mitra, Dipak Kumar
Ahmed, Shakil
author_facet Mahmood, Rudbar
Benzadid, Md. Shadly
Weston, Sophie
Hossain, Ahmed
Ahmed, Tanveer
Mitra, Dipak Kumar
Ahmed, Shakil
author_sort Mahmood, Rudbar
collection PubMed
description BACKGROUND: Dengue fever has been one of the most common mosquito-transmitted diseases in the world, affecting more than 128 countries in both tropical and subtropical regions. Bangladesh has been sufferring from dengue outbreaks almost annually since 2000, and in 2019, Bangladesh faced the worst outbreak of dengue to date. This study aimed to provide clinical and biochemical profiles of Bangladesh's dengue-infected patients. METHODS: This cross-sectional study was conducted from August through December 2019 in three tertiary private hospitals in Dhaka, Bangladesh. We collected information on demographic data, clinical characteristics, and laboratory profiles for 542 confirmed hospitalized acute dengue cases using a structured questionnaire. RESULTS: The average age of the enrolled patients was 26.15 years, and about 50% of patients belonged to the age group of 20–40 years. The most frequent among the prevalent clinical symptoms were fever (93.1%), abdominal pain (29.5%), skin rash (25.3%), and diarrhea (19.7%). 316 patients had some complications, such as breathing problems (41.4%), pleural effusion (38.9%), gum bleeding (11.1%), etc. More than 90% of the patients showed seropositivity for the DENV-NS1 antigen. CONCLUSIONS: Over the last couple of years, dengue fever has become a major health issue for Bangladesh. To reduce the burden of this disease, timely diagnosis and prompt treatment are necessary. This analysis thus yields the clinical features, laboratory profiles, and seropositivity test results of dengue patients from Bangladesh. The research results may help clinicians understand the circumstantial diagnosis of dengue patients and facilitate early intervention.
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spelling pubmed-81880502021-06-16 Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city Mahmood, Rudbar Benzadid, Md. Shadly Weston, Sophie Hossain, Ahmed Ahmed, Tanveer Mitra, Dipak Kumar Ahmed, Shakil Heliyon Research Article BACKGROUND: Dengue fever has been one of the most common mosquito-transmitted diseases in the world, affecting more than 128 countries in both tropical and subtropical regions. Bangladesh has been sufferring from dengue outbreaks almost annually since 2000, and in 2019, Bangladesh faced the worst outbreak of dengue to date. This study aimed to provide clinical and biochemical profiles of Bangladesh's dengue-infected patients. METHODS: This cross-sectional study was conducted from August through December 2019 in three tertiary private hospitals in Dhaka, Bangladesh. We collected information on demographic data, clinical characteristics, and laboratory profiles for 542 confirmed hospitalized acute dengue cases using a structured questionnaire. RESULTS: The average age of the enrolled patients was 26.15 years, and about 50% of patients belonged to the age group of 20–40 years. The most frequent among the prevalent clinical symptoms were fever (93.1%), abdominal pain (29.5%), skin rash (25.3%), and diarrhea (19.7%). 316 patients had some complications, such as breathing problems (41.4%), pleural effusion (38.9%), gum bleeding (11.1%), etc. More than 90% of the patients showed seropositivity for the DENV-NS1 antigen. CONCLUSIONS: Over the last couple of years, dengue fever has become a major health issue for Bangladesh. To reduce the burden of this disease, timely diagnosis and prompt treatment are necessary. This analysis thus yields the clinical features, laboratory profiles, and seropositivity test results of dengue patients from Bangladesh. The research results may help clinicians understand the circumstantial diagnosis of dengue patients and facilitate early intervention. Elsevier 2021-05-29 /pmc/articles/PMC8188050/ /pubmed/34141938 http://dx.doi.org/10.1016/j.heliyon.2021.e07183 Text en © 2021 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Mahmood, Rudbar
Benzadid, Md. Shadly
Weston, Sophie
Hossain, Ahmed
Ahmed, Tanveer
Mitra, Dipak Kumar
Ahmed, Shakil
Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title_full Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title_fullStr Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title_full_unstemmed Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title_short Dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in Dhaka city
title_sort dengue outbreak 2019: clinical and laboratory profiles of dengue virus infection in dhaka city
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188050/
https://www.ncbi.nlm.nih.gov/pubmed/34141938
http://dx.doi.org/10.1016/j.heliyon.2021.e07183
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