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Single‐Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Molecular heterogeneity of hepatobiliary tumor including intertumoral and intratumoral disparity always leads to drug resistance. Here, seven hepatobiliary tumor organoids are generated to explore heterogeneity and evolution via single‐cell RNA sequencing. HCC272 with high status of epithelia‐mesenc...

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Detalles Bibliográficos
Autores principales:	Zhao, Yan, Li, Zhi‐Xuan, Zhu, Yan‐Jing, Fu, Jing, Zhao, Xiao‐Fang, Zhang, Ya‐Ni, Wang, Shan, Wu, Jian‐Min, Wang, Kai‐Ting, Wu, Rui, Sui, Cheng‐Jun, Shen, Si‐Yun, Wu, Xuan, Wang, Hong‐Yang, Gao, Dong, Chen, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Full Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188185/ https://www.ncbi.nlm.nih.gov/pubmed/34105295 http://dx.doi.org/10.1002/advs.202003897

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