Mistranslation Drives Alterations in Protein Levels and the Effects of a Synonymous Variant at the Fibroblast Growth Factor 21 Locus

Fibroblast growth factor 21 (FGF21) is a liver‐derived hormone with pleiotropic beneficial effects on metabolism. Paradoxically, FGF21 levels are elevated in metabolic diseases. Interventions that restore metabolic homeostasis reduce FGF21. Whether abnormalities in FGF21 secretion or resistance in p...

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Detalles Bibliográficos
Autores principales: Bayoumi, Ali, Elsayed, Asmaa, Han, Shuanglin, Petta, Salvatore, Adams, Leon A., Aller, Rocio, Khan, Anis, García‐Monzón, Carmelo, Arias‐Loste, María Teresa, Miele, Luca, Latchoumanin, Olivier, Alenizi, Shafi, Gallego‐Durán, Rocio, Fischer, Janett, Berg, Thomas, Craxì, Antonio, Metwally, Mayada, Qiao, Liang, Liddle, Christopher, Yki‐Järvinen, Hannele, Bugianesi, Elisabetta, Romero‐Gomez, Manuel, George, Jacob, Eslam, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188187/
https://www.ncbi.nlm.nih.gov/pubmed/34141520
http://dx.doi.org/10.1002/advs.202004168

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