Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

COVID-19 can cause severe neurological symptoms, but the underlying pathophysiological mechanisms are unclear. Here, we interrogated the brain stems and olfactory bulbs in postmortem patients who had COVID-19 using imaging mass cytometry to understand the local immune response at a spatially resolve...

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Detalles Bibliográficos
Autores principales: Schwabenland, Marius, Salié, Henrike, Tanevski, Jovan, Killmer, Saskia, Lago, Marilyn Salvat, Schlaak, Alexandra Emilia, Mayer, Lena, Matschke, Jakob, Püschel, Klaus, Fitzek, Antonia, Ondruschka, Benjamin, Mei, Henrik E., Boettler, Tobias, Neumann-Haefelin, Christoph, Hofmann, Maike, Breithaupt, Angele, Genc, Nafiye, Stadelmann, Christine, Saez-Rodriguez, Julio, Bronsert, Peter, Knobeloch, Klaus-Peter, Blank, Thomas, Thimme, Robert, Glatzel, Markus, Prinz, Marco, Bengsch, Bertram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188302/
https://www.ncbi.nlm.nih.gov/pubmed/34174183
http://dx.doi.org/10.1016/j.immuni.2021.06.002

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