Cargando…

C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons

RNA-binding proteins (RBPs) play essential roles in diverse cellular processes through post-transcriptional regulation of RNAs. The subcellular localization of RBPs is thus under tight control, the breakdown of which is associated with aberrant cytoplasmic accumulation of nuclear RBPs such as TDP-43...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Eun Seon, Chung, Chang Geon, Park, Jeong Hyang, Ko, Byung Su, Park, Sung Soon, Kim, Yoon Ha, Cha, In Jun, Kim, Jaekwang, Ha, Chang Man, Kim, Hyung-Jun, Lee, Sung Bae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188407/ https://www.ncbi.nlm.nih.gov/pubmed/33783499 http://dx.doi.org/10.1093/hmg/ddab089

Ejemplares similares

C9orf72-Associated Arginine-Rich Dipeptide Repeat Proteins Reduce the Number of Golgi Outposts and Dendritic Branches in Drosophila Neurons
por: Park, Jeong Hyang, et al.
Publicado: (2020)

The Proline/Arginine Dipeptide from Hexanucleotide Repeat Expanded C9ORF72 Inhibits the Proteasome
por: Gupta, Rahul, et al.
Publicado: (2017)

C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
por: Hayes, Lindsey R, et al.
Publicado: (2020)

Impaired ribosome-associated quality control of C9orf72 arginine-rich dipeptide-repeat proteins
por: Viera Ortiz, Ashley P, et al.
Publicado: (2022)

Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides
por: Kanekura, Kohsuke, et al.
Publicado: (2018)

C9orf72-derived arginine-rich poly-dipeptides impede phase modifiers
por: Nanaura, Hitoki, et al.
Publicado: (2021)

Type I PRMT Inhibition Protects Against C9ORF72 Arginine-Rich Dipeptide Repeat Toxicity
por: Premasiri, Alan S., et al.
Publicado: (2020)

C9orf72-Derived Proline:Arginine Poly-Dipeptides Modulate Cytoskeleton and Mechanical Stress Response
por: Shiota, Tomo, et al.
Publicado: (2022)

The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD
por: Freibaum, Brian D., et al.
Publicado: (2017)

SFPQ regulates the accumulation of RNA foci and dipeptide repeat proteins from the expanded repeat mutation in C9orf72
por: Malnar, Mirjana, et al.
Publicado: (2021)

C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
por: Sun, Yu, et al.
Publicado: (2020)

C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility
por: Fumagalli, Laura, et al.
Publicado: (2021)

Differential toxicity and localization of arginine-rich C9ORF72 dipeptide repeat proteins depend on de-clustering of positive charges
por: Miyagi, Tamami, et al.
Publicado: (2023)

Emerging Perspectives on Dipeptide Repeat Proteins in C9ORF72 ALS/FTD
por: Schmitz, Alexander, et al.
Publicado: (2021)

Nuclear localized C9orf72-associated arginine-containing dipeptides exhibit age-dependent toxicity in C. elegans
por: Rudich, Paige, et al.
Publicado: (2017)

Publisher Correction: C9orf72 arginine-rich dipeptide repeats inhibit UPF1-mediated RNA decay via translational repression
por: Sun, Yu, et al.
Publicado: (2022)

Distinct C9orf72-Associated Dipeptide Repeat Structures Correlate with Neuronal Toxicity
por: Flores, Brittany N., et al.
Publicado: (2016)

Modelling C9orf72 dipeptide repeat proteins of a physiologically relevant size
por: Bennion Callister, Janis, et al.
Publicado: (2016)

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics
por: Boeynaems, Steven, et al.
Publicado: (2017)

Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression
por: McGoldrick, Philip, et al.
Publicado: (2018)

Accumulation of dipeptide repeat proteins predates that of TDP‐43 in frontotemporal lobar degeneration associated with hexanucleotide repeat expansions in C9ORF72 gene
por: Baborie, Atik, et al.
Publicado: (2015)

Staufen1-mediated mRNA decay induces Requiem mRNA decay through binding of Staufen1 to the Requiem 3′UTR
por: Kim, Min Young, et al.
Publicado: (2014)

Dipeptide repeat (DPR) pathology in the skeletal muscle of ALS patients with C9ORF72 repeat expansion
por: Cykowski, Matthew D., et al.
Publicado: (2019)

Antibodies inhibit transmission and aggregation of C9orf72 poly‐GA dipeptide repeat proteins
por: Zhou, Qihui, et al.
Publicado: (2017)

Toxicity of C9orf72-associated dipeptide repeat peptides is modified by commonly used protein tags
por: Morón-Oset, Javier, et al.
Publicado: (2023)

Investigation of the effect of Staufen1 overexpression on the HIV-1 virus production
por: Park, Seong-won, et al.
Publicado: (2021)

Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides
por: Balendra, Rubika, et al.
Publicado: (2023)

Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity
por: Xu, Wangchao, et al.
Publicado: (2019)

Interactome screening of C9orf72 dipeptide repeats reveals VCP sequestration and functional impairment by polyGA
por: Božič, Janja, et al.
Publicado: (2021)

Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance
por: Jiménez-Villegas, José, et al.
Publicado: (2022)

A mouse model with widespread expression of the C9orf72-linked glycine–arginine dipeptide displays non-lethal ALS/FTD-like phenotypes
por: Verdone, Brandie Morris, et al.
Publicado: (2022)

Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity
por: Bennett, Craig L., et al.
Publicado: (2023)

Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing
por: Schludi, Martin H., et al.
Publicado: (2015)

Glycine-alanine dipeptide repeat protein contributes to toxicity in a zebrafish model of C9orf72 associated neurodegeneration
por: Ohki, Yu, et al.
Publicado: (2017)

CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts
por: Tabet, Ricardos, et al.
Publicado: (2018)

Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients
por: Mordes, Daniel A., et al.
Publicado: (2018)

Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease
por: Sakae, Nobutaka, et al.
Publicado: (2018)

Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation
por: Liu, Feilin, et al.
Publicado: (2022)

Poly-dipeptides produced from C9orf72 hexanucleotide repeats cause selective motor neuron hyperexcitability in ALS
por: Jo, Yunhee, et al.
Publicado: (2022)

Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons
por: Sonobe, Yoshifumi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_bvti44up56btm49ntq4d6fa8uv