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Hit-optimization using target-directed dynamic combinatorial chemistry: development of inhibitors of the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase

Target-directed dynamic combinatorial chemistry (tdDCC) enables identification, as well as optimization of ligands for un(der)explored targets such as the anti-infective target 1-deoxy-d-xylulose-5-phosphate synthase (DXPS). We report the use of tdDCC to first identify and subsequently optimize bind...

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Detalles Bibliográficos
Autores principales:	Jumde, Ravindra P., Guardigni, Melissa, Gierse, Robin M., Alhayek, Alaa, Zhu, Di, Hamid, Zhoor, Johannsen, Sandra, Elgaher, Walid A. M., Neusens, Philipp J., Nehls, Christian, Haupenthal, Jörg, Reiling, Norbert, Hirsch, Anna K. H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society of Chemistry 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188608/ https://www.ncbi.nlm.nih.gov/pubmed/34168831 http://dx.doi.org/10.1039/d1sc00330e

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