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A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the development a...

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Detalles Bibliográficos
Autores principales: Mlakar, Vid, Morel, Edouard, Mlakar, Simona Jurkovic, Ansari, Marc, Gumy-Pause, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188681/
https://www.ncbi.nlm.nih.gov/pubmed/34103089
http://dx.doi.org/10.1186/s13046-021-01967-x
Descripción
Sumario:Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway’s involvement in neuroblastoma. We discuss the RAS-MAPK pathway’s general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-021-01967-x.