A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma

Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the development a...

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Autores principales: Mlakar, Vid, Morel, Edouard, Mlakar, Simona Jurkovic, Ansari, Marc, Gumy-Pause, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188681/
https://www.ncbi.nlm.nih.gov/pubmed/34103089
http://dx.doi.org/10.1186/s13046-021-01967-x
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author Mlakar, Vid
Morel, Edouard
Mlakar, Simona Jurkovic
Ansari, Marc
Gumy-Pause, Fabienne
author_facet Mlakar, Vid
Morel, Edouard
Mlakar, Simona Jurkovic
Ansari, Marc
Gumy-Pause, Fabienne
author_sort Mlakar, Vid
collection PubMed
description Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway’s involvement in neuroblastoma. We discuss the RAS-MAPK pathway’s general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-021-01967-x.
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spelling pubmed-81886812021-06-10 A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma Mlakar, Vid Morel, Edouard Mlakar, Simona Jurkovic Ansari, Marc Gumy-Pause, Fabienne J Exp Clin Cancer Res Review Neuroblastoma is the most common extra-cranial solid tumor in children, representing approximately 8% of all malignant childhood tumors and 15% of pediatric cancer-related deaths. Recent sequencing and transcriptomics studies have demonstrated the RAS-MAPK pathway’s contribution to the development and progression of neuroblastoma. This review compiles up-to-date evidence of this pathway’s involvement in neuroblastoma. We discuss the RAS-MAPK pathway’s general functioning, the clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13046-021-01967-x. BioMed Central 2021-06-08 /pmc/articles/PMC8188681/ /pubmed/34103089 http://dx.doi.org/10.1186/s13046-021-01967-x Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Mlakar, Vid
Morel, Edouard
Mlakar, Simona Jurkovic
Ansari, Marc
Gumy-Pause, Fabienne
A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title_full A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title_fullStr A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title_full_unstemmed A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title_short A review of the biological and clinical implications of RAS-MAPK pathway alterations in neuroblastoma
title_sort review of the biological and clinical implications of ras-mapk pathway alterations in neuroblastoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188681/
https://www.ncbi.nlm.nih.gov/pubmed/34103089
http://dx.doi.org/10.1186/s13046-021-01967-x
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