Reproductive history determines Erbb2 locus amplification, WNT signalling and tumour phenotype in a murine breast cancer model

Understanding the mechanisms underlying tumour heterogeneity is key to the development of treatments that can target specific tumour subtypes. We have previously targeted CRE recombinase-dependent conditional deletion of the tumour suppressor genes Brca1, Brca2, p53 (also known as Trp53) and/or Pten...

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Detalles Bibliográficos
Autores principales: Ordonez, Liliana D., Melchor, Lorenzo, Greenow, Kirsty R., Kendrick, Howard, Tornillo, Giusy, Bradford, James, Giles, Peter, Smalley, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188886/
https://www.ncbi.nlm.nih.gov/pubmed/34003256
http://dx.doi.org/10.1242/dmm.048736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188886/
https://www.ncbi.nlm.nih.gov/pubmed/34003256
http://dx.doi.org/10.1242/dmm.048736

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