Linezolid-induced serotonin syndrome

Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid,...

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Autores principales: Shouan, Anish, Kumar, Rajeet, Lal, Vivek, Grover, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188929/
https://www.ncbi.nlm.nih.gov/pubmed/34158725
http://dx.doi.org/10.4103/ipj.ipj_37_19
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author Shouan, Anish
Kumar, Rajeet
Lal, Vivek
Grover, Sandeep
author_facet Shouan, Anish
Kumar, Rajeet
Lal, Vivek
Grover, Sandeep
author_sort Shouan, Anish
collection PubMed
description Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid, when used alone. In this report, we present the case of a 70-year-old female who developed features of SS while being treated with linezolid 600 mg twice daily for pneumonia. The SS in her case was managed with stoppage of linezolid, administration of cyproheptadine, and supportive measures.
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spelling pubmed-81889292021-06-21 Linezolid-induced serotonin syndrome Shouan, Anish Kumar, Rajeet Lal, Vivek Grover, Sandeep Ind Psychiatry J Case Report Linezolid is an oxazolidinone antibiotic, which is a weak, reversible, nonselective monoamine oxidase A and B inhibitor; is known to increase serotonin levels, and has been implicated in the development of serotonin syndrome (SS). There is limited literature on the development of SS with linezolid, when used alone. In this report, we present the case of a 70-year-old female who developed features of SS while being treated with linezolid 600 mg twice daily for pneumonia. The SS in her case was managed with stoppage of linezolid, administration of cyproheptadine, and supportive measures. Wolters Kluwer - Medknow 2020 2021-03-15 /pmc/articles/PMC8188929/ /pubmed/34158725 http://dx.doi.org/10.4103/ipj.ipj_37_19 Text en Copyright: © 2021 Industrial Psychiatry Journal https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Shouan, Anish
Kumar, Rajeet
Lal, Vivek
Grover, Sandeep
Linezolid-induced serotonin syndrome
title Linezolid-induced serotonin syndrome
title_full Linezolid-induced serotonin syndrome
title_fullStr Linezolid-induced serotonin syndrome
title_full_unstemmed Linezolid-induced serotonin syndrome
title_short Linezolid-induced serotonin syndrome
title_sort linezolid-induced serotonin syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8188929/
https://www.ncbi.nlm.nih.gov/pubmed/34158725
http://dx.doi.org/10.4103/ipj.ipj_37_19
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AT kumarrajeet linezolidinducedserotoninsyndrome
AT lalvivek linezolidinducedserotoninsyndrome
AT groversandeep linezolidinducedserotoninsyndrome

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