Cargando…

The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses

Approximately 15% of infants worldwide are born with low birthweight (<2500 g). These children are at risk for growth failure. The aim of this umbrella review is to assess the relationship between infant milk type, fortification and growth in low‐birthweight infants, with particular focus on low‐...

Descripción completa

Detalles Bibliográficos
Autores principales: North, Krysten, Marx Delaney, Megan, Bose, Carl, Lee, Anne C. C., Vesel, Linda, Adair, Linda, Semrau, Katherine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189224/
https://www.ncbi.nlm.nih.gov/pubmed/33733580
http://dx.doi.org/10.1111/mcn.13176
_version_ 1783705467055243264
author North, Krysten
Marx Delaney, Megan
Bose, Carl
Lee, Anne C. C.
Vesel, Linda
Adair, Linda
Semrau, Katherine
author_facet North, Krysten
Marx Delaney, Megan
Bose, Carl
Lee, Anne C. C.
Vesel, Linda
Adair, Linda
Semrau, Katherine
author_sort North, Krysten
collection PubMed
description Approximately 15% of infants worldwide are born with low birthweight (<2500 g). These children are at risk for growth failure. The aim of this umbrella review is to assess the relationship between infant milk type, fortification and growth in low‐birthweight infants, with particular focus on low‐ and lower middle–income countries. We conducted a systematic review in PubMed, CINAHL, Embase and Web of Science comparing infant milk options and growth, grading the strength of evidence based on standard umbrella review criteria. Twenty‐six systematic reviews qualified for inclusion. They predominantly focused on infants with very low birthweight (<1500 g) in high‐income countries. We found the strongest evidence for (1) the addition of energy and protein fortification to human milk (donor or mother's milk) leading to increased weight gain (mean difference [MD] 1.81 g/kg/day; 95% confidence interval [CI] 1.23, 2.40), linear growth (MD 0.18 cm/week; 95% CI 0.10, 0.26) and head growth (MD 0.08 cm/week; 95% CI 0.04, 0.12) and (2) formula compared with donor human milk leading to increased weight gain (MD 2.51 g/kg/day; 95% CI 1.93, 3.08), linear growth (MD 1.21 mm/week; 95% CI 0.77, 1.65) and head growth (MD 0.85 mm/week; 95% CI 0.47, 1.23). We also found evidence of improved growth when protein is added to both human milk and formula. Fat supplementation did not seem to affect growth. More research is needed for infants with birthweight 1500–2500 g in low‐ and lower middle–income countries.
format Online
Article
Text
id pubmed-8189224
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-81892242021-06-16 The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses North, Krysten Marx Delaney, Megan Bose, Carl Lee, Anne C. C. Vesel, Linda Adair, Linda Semrau, Katherine Matern Child Nutr Review Articles Approximately 15% of infants worldwide are born with low birthweight (<2500 g). These children are at risk for growth failure. The aim of this umbrella review is to assess the relationship between infant milk type, fortification and growth in low‐birthweight infants, with particular focus on low‐ and lower middle–income countries. We conducted a systematic review in PubMed, CINAHL, Embase and Web of Science comparing infant milk options and growth, grading the strength of evidence based on standard umbrella review criteria. Twenty‐six systematic reviews qualified for inclusion. They predominantly focused on infants with very low birthweight (<1500 g) in high‐income countries. We found the strongest evidence for (1) the addition of energy and protein fortification to human milk (donor or mother's milk) leading to increased weight gain (mean difference [MD] 1.81 g/kg/day; 95% confidence interval [CI] 1.23, 2.40), linear growth (MD 0.18 cm/week; 95% CI 0.10, 0.26) and head growth (MD 0.08 cm/week; 95% CI 0.04, 0.12) and (2) formula compared with donor human milk leading to increased weight gain (MD 2.51 g/kg/day; 95% CI 1.93, 3.08), linear growth (MD 1.21 mm/week; 95% CI 0.77, 1.65) and head growth (MD 0.85 mm/week; 95% CI 0.47, 1.23). We also found evidence of improved growth when protein is added to both human milk and formula. Fat supplementation did not seem to affect growth. More research is needed for infants with birthweight 1500–2500 g in low‐ and lower middle–income countries. John Wiley and Sons Inc. 2021-03-17 /pmc/articles/PMC8189224/ /pubmed/33733580 http://dx.doi.org/10.1111/mcn.13176 Text en © 2021 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Articles
North, Krysten
Marx Delaney, Megan
Bose, Carl
Lee, Anne C. C.
Vesel, Linda
Adair, Linda
Semrau, Katherine
The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title_full The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title_fullStr The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title_full_unstemmed The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title_short The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
title_sort effect of milk type and fortification on the growth of low‐birthweight infants: an umbrella review of systematic reviews and meta‐analyses
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189224/
https://www.ncbi.nlm.nih.gov/pubmed/33733580
http://dx.doi.org/10.1111/mcn.13176
work_keys_str_mv AT northkrysten theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT marxdelaneymegan theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT bosecarl theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT leeannecc theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT vesellinda theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT adairlinda theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT semraukatherine theeffectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT northkrysten effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT marxdelaneymegan effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT bosecarl effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT leeannecc effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT vesellinda effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT adairlinda effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses
AT semraukatherine effectofmilktypeandfortificationonthegrowthoflowbirthweightinfantsanumbrellareviewofsystematicreviewsandmetaanalyses