Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase

Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, the substrates and specificity of most UPS components are not well understood. Here we systematically characterized the UPS in Saccharomyces cerevisiae. Using fluorescent timers, we...

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Detalles Bibliográficos
Autores principales: Kong, Ka-Yiu Edwin, Fischer, Bernd, Meurer, Matthias, Kats, Ilia, Li, Zhaoyan, Rühle, Frank, Barry, Joseph D., Kirrmaier, Daniel, Chevyreva, Veronika, San Luis, Bryan-Joseph, Costanzo, Michael, Huber, Wolfgang, Andrews, Brenda J., Boone, Charles, Knop, Michael, Khmelinskii, Anton
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189435/
https://www.ncbi.nlm.nih.gov/pubmed/33974913
http://dx.doi.org/10.1016/j.molcel.2021.04.018

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