GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

How are E3 ubiquitin ligases configured to match substrate quaternary structures? Here, by studying the yeast GID complex (mutation of which causes deficiency in glucose-induced degradation of gluconeogenic enzymes), we discover supramolecular chelate assembly as an E3 ligase strategy for targeting...

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Detalles Bibliográficos
Autores principales: Sherpa, Dawafuti, Chrustowicz, Jakub, Qiao, Shuai, Langlois, Christine R., Hehl, Laura A., Gottemukkala, Karthik Varma, Hansen, Fynn M., Karayel, Ozge, von Gronau, Susanne, Prabu, J. Rajan, Mann, Matthias, Alpi, Arno F., Schulman, Brenda A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189437/
https://www.ncbi.nlm.nih.gov/pubmed/33905682
http://dx.doi.org/10.1016/j.molcel.2021.03.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189437/
https://www.ncbi.nlm.nih.gov/pubmed/33905682
http://dx.doi.org/10.1016/j.molcel.2021.03.025

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