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Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells

Cancer cells adapt their metabolism to support elevated energetic and anabolic demands of proliferation. Folate-dependent one-carbon metabolism is a critical metabolic process underpinning cellular proliferation supplying carbons for the synthesis of nucleotides incorporated into DNA and RNA. Recent...

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Detalles Bibliográficos
Autores principales:	Newman, Alice Clare, Falcone, Mattia, Huerta Uribe, Alejandro, Zhang, Tong, Athineos, Dimitris, Pietzke, Matthias, Vazquez, Alexei, Blyth, Karen, Maddocks, Oliver David Kenneth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189438/ https://www.ncbi.nlm.nih.gov/pubmed/33831358 http://dx.doi.org/10.1016/j.molcel.2021.03.019

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