Cargando…

Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study

BACKGROUND: We compared influenza antibody titers among vaccinated and unvaccinated pregnant and non-pregnant women. METHODS: During 1(st) June– 30(th) September 2018, four groups of cohort participants—vaccinated pregnant, unvaccinated pregnant, vaccinated non-pregnant, and unvaccinated non-pregnan...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakphook, Sutthichai, Patumanond, Jayanton, Shrestha, Manash, Prasert, Kriengkrai, Chittaganpitch, Malinee, Mott, Joshua A., Praphasiri, Prabda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189519/
https://www.ncbi.nlm.nih.gov/pubmed/34106994
http://dx.doi.org/10.1371/journal.pone.0253028
_version_ 1783705514038788096
author Nakphook, Sutthichai
Patumanond, Jayanton
Shrestha, Manash
Prasert, Kriengkrai
Chittaganpitch, Malinee
Mott, Joshua A.
Praphasiri, Prabda
author_facet Nakphook, Sutthichai
Patumanond, Jayanton
Shrestha, Manash
Prasert, Kriengkrai
Chittaganpitch, Malinee
Mott, Joshua A.
Praphasiri, Prabda
author_sort Nakphook, Sutthichai
collection PubMed
description BACKGROUND: We compared influenza antibody titers among vaccinated and unvaccinated pregnant and non-pregnant women. METHODS: During 1(st) June– 30(th) September 2018, four groups of cohort participants—vaccinated pregnant, unvaccinated pregnant, vaccinated non-pregnant, and unvaccinated non-pregnant women were selected by matching age, gestational age, and the week of vaccination. Serum antibody titers against each strain of 2018 Southern Hemisphere inactivated trivalent influenza vaccine (IIV3) were assessed by hemagglutination inhibition (HI) assay on Day 0 (pre-vaccination) and Day 28 (one month post-vaccination) serum samples. Geometric mean titer (GMT), GMT ratio (GMR), seroconversion (defined as ≥4 fold increase in HI titer), and seroprotection (i.e. HI titer ≥1:40) were compared across the study groups using multilevel regression analyses, controlling for previous year vaccination from medical records and baseline antibody levels. RESULTS: A total of 132 participants were enrolled in the study (33 in each of the four study groups). The baseline GMTs for influenza A(H1N1), A(H3N2), and B vaccine strains were not significantly different among all four groups (all p-values >0.05). After one month, both vaccinated groups had significantly higher GMT, GMR, seroconversion, and seroprotection than their unvaccinated controls (all p-values <0.05). The seroconversion rate was over 60% for any strain among the vaccinated groups, with the highest (88.8%) observed against A(H1N1) in the vaccinated pregnant group. Similarly, at least 75% of the vaccinated participants developed seroprotective antibody levels against all three strains; the highest seroprotection was found against A(H3N2) at 92.6% among vaccinated non-pregnant participants. Antibody responses (post-vaccination GMT, GMR, seroconversion, and seroprotection) were not significantly different between pregnant and non-pregnant women for all three strains of IIV3 (all p>0.05). CONCLUSIONS: The 2018 seasonal IIV3 was immunogenic against all three vaccine strains and pregnancy did not seem to alter the immune response to IIV3. These findings support the current influenza vaccination recommendations for pregnant women.
format Online
Article
Text
id pubmed-8189519
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-81895192021-06-10 Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study Nakphook, Sutthichai Patumanond, Jayanton Shrestha, Manash Prasert, Kriengkrai Chittaganpitch, Malinee Mott, Joshua A. Praphasiri, Prabda PLoS One Research Article BACKGROUND: We compared influenza antibody titers among vaccinated and unvaccinated pregnant and non-pregnant women. METHODS: During 1(st) June– 30(th) September 2018, four groups of cohort participants—vaccinated pregnant, unvaccinated pregnant, vaccinated non-pregnant, and unvaccinated non-pregnant women were selected by matching age, gestational age, and the week of vaccination. Serum antibody titers against each strain of 2018 Southern Hemisphere inactivated trivalent influenza vaccine (IIV3) were assessed by hemagglutination inhibition (HI) assay on Day 0 (pre-vaccination) and Day 28 (one month post-vaccination) serum samples. Geometric mean titer (GMT), GMT ratio (GMR), seroconversion (defined as ≥4 fold increase in HI titer), and seroprotection (i.e. HI titer ≥1:40) were compared across the study groups using multilevel regression analyses, controlling for previous year vaccination from medical records and baseline antibody levels. RESULTS: A total of 132 participants were enrolled in the study (33 in each of the four study groups). The baseline GMTs for influenza A(H1N1), A(H3N2), and B vaccine strains were not significantly different among all four groups (all p-values >0.05). After one month, both vaccinated groups had significantly higher GMT, GMR, seroconversion, and seroprotection than their unvaccinated controls (all p-values <0.05). The seroconversion rate was over 60% for any strain among the vaccinated groups, with the highest (88.8%) observed against A(H1N1) in the vaccinated pregnant group. Similarly, at least 75% of the vaccinated participants developed seroprotective antibody levels against all three strains; the highest seroprotection was found against A(H3N2) at 92.6% among vaccinated non-pregnant participants. Antibody responses (post-vaccination GMT, GMR, seroconversion, and seroprotection) were not significantly different between pregnant and non-pregnant women for all three strains of IIV3 (all p>0.05). CONCLUSIONS: The 2018 seasonal IIV3 was immunogenic against all three vaccine strains and pregnancy did not seem to alter the immune response to IIV3. These findings support the current influenza vaccination recommendations for pregnant women. Public Library of Science 2021-06-09 /pmc/articles/PMC8189519/ /pubmed/34106994 http://dx.doi.org/10.1371/journal.pone.0253028 Text en https://creativecommons.org/publicdomain/zero/1.0/This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 (https://creativecommons.org/publicdomain/zero/1.0/) public domain dedication.
spellingShingle Research Article
Nakphook, Sutthichai
Patumanond, Jayanton
Shrestha, Manash
Prasert, Kriengkrai
Chittaganpitch, Malinee
Mott, Joshua A.
Praphasiri, Prabda
Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title_full Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title_fullStr Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title_full_unstemmed Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title_short Antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in Thailand: A matched cohort study
title_sort antibody responses induced by trivalent inactivated influenza vaccine among pregnant and non-pregnant women in thailand: a matched cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189519/
https://www.ncbi.nlm.nih.gov/pubmed/34106994
http://dx.doi.org/10.1371/journal.pone.0253028
work_keys_str_mv AT nakphooksutthichai antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT patumanondjayanton antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT shresthamanash antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT prasertkriengkrai antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT chittaganpitchmalinee antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT mottjoshuaa antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy
AT praphasiriprabda antibodyresponsesinducedbytrivalentinactivatedinfluenzavaccineamongpregnantandnonpregnantwomeninthailandamatchedcohortstudy