The stability of R-spine defines RAF inhibitor resistance: A comprehensive analysis of oncogenic BRAF mutants with in-frame insertion of αC-β4 loop

Although targeting BRAF mutants with RAF inhibitors has achieved promising outcomes in cancer therapy, drug resistance remains a remarkable challenge, and underlying molecular mechanisms are not fully understood. Here, we characterized a previously unknown group of oncogenic BRAF mutants with in-fra...

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Detalles Bibliográficos
Autores principales: Yap, Jiajun, Deepak, R. N. V. Krishna, Tian, Zizi, Ng, Wan Hwa, Goh, Kah Chun, Foo, Alicia, Tee, Zi Heng, Mohanam, Manju Payini, Sim, Yuen Rong M., Degirmenci, Ufuk, Lam, Paula, Chen, Zhongzhou, Fan, Hao, Hu, Jiancheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189578/
https://www.ncbi.nlm.nih.gov/pubmed/34108213
http://dx.doi.org/10.1126/sciadv.abg0390

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