Development of next-generation tumor-homing induced neural stem cells to enhance treatment of metastatic cancers

Engineered tumor-homing neural stem cells (NSCs) have shown promise in treating cancer. Recently, we transdifferentiated skin fibroblasts into human-induced NSCs (hiNSC) as personalized NSC drug carriers. Here, using a SOX2 and spheroidal culture-based reprogramming strategy, we generated a new hiNS...

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Detalles Bibliográficos
Autores principales: Jiang, Wulin, Yang, Yuchen, Mercer-Smith, Alison R., Valdivia, Alain, Bago, Juli R., Woodell, Alex S., Buckley, Andrew A., Marand, Michael H., Qian, Li, Anders, Carey K., Hingtgen, Shawn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189583/
https://www.ncbi.nlm.nih.gov/pubmed/34108203
http://dx.doi.org/10.1126/sciadv.abf1526

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