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Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness
Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortica...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189589/ https://www.ncbi.nlm.nih.gov/pubmed/34108214 http://dx.doi.org/10.1126/sciadv.abg1512 |
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author | McCutcheon, Robert A. Brown, Kirsten Nour, Matthew M. Smith, Stephen M. Veronese, Mattia Zelaya, Fernando Osugo, Martin Jauhar, Sameer Hallett, William Mehta, Mitul M. Howes, Oliver D. |
author_facet | McCutcheon, Robert A. Brown, Kirsten Nour, Matthew M. Smith, Stephen M. Veronese, Mattia Zelaya, Fernando Osugo, Martin Jauhar, Sameer Hallett, William Mehta, Mitul M. Howes, Oliver D. |
author_sort | McCutcheon, Robert A. |
collection | PubMed |
description | Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortical activity and dopamine signaling coexist. Using simultaneous PET-MRI in healthy volunteers, we find strong evidence that patterns of striatal dopamine signaling and cortical blood flow (an index of local neural activity) contain shared information. This shared information links amphetamine-induced changes in gradients of striatal dopamine receptor availability to changes in brain-wide blood flow and is informed by spatial patterns of gene expression enriched for genes implicated in schizophrenia, bipolar disorder, and autism spectrum disorder. These results advance our knowledge of the relationship between cortical function and striatal dopamine, with relevance for understanding pathophysiology and treatment of diseases in which simultaneous aberrations of these systems exist. |
format | Online Article Text |
id | pubmed-8189589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-81895892021-06-22 Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness McCutcheon, Robert A. Brown, Kirsten Nour, Matthew M. Smith, Stephen M. Veronese, Mattia Zelaya, Fernando Osugo, Martin Jauhar, Sameer Hallett, William Mehta, Mitul M. Howes, Oliver D. Sci Adv Research Articles Dopamine signaling is constrained to discrete tracts yet has brain-wide effects on neural activity. The nature of this relationship between local dopamine signaling and brain-wide neuronal activity is not clearly defined and has relevance for neuropsychiatric illnesses where abnormalities of cortical activity and dopamine signaling coexist. Using simultaneous PET-MRI in healthy volunteers, we find strong evidence that patterns of striatal dopamine signaling and cortical blood flow (an index of local neural activity) contain shared information. This shared information links amphetamine-induced changes in gradients of striatal dopamine receptor availability to changes in brain-wide blood flow and is informed by spatial patterns of gene expression enriched for genes implicated in schizophrenia, bipolar disorder, and autism spectrum disorder. These results advance our knowledge of the relationship between cortical function and striatal dopamine, with relevance for understanding pathophysiology and treatment of diseases in which simultaneous aberrations of these systems exist. American Association for the Advancement of Science 2021-06-09 /pmc/articles/PMC8189589/ /pubmed/34108214 http://dx.doi.org/10.1126/sciadv.abg1512 Text en Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles McCutcheon, Robert A. Brown, Kirsten Nour, Matthew M. Smith, Stephen M. Veronese, Mattia Zelaya, Fernando Osugo, Martin Jauhar, Sameer Hallett, William Mehta, Mitul M. Howes, Oliver D. Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title_full | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title_fullStr | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title_full_unstemmed | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title_short | Dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
title_sort | dopaminergic organization of striatum is linked to cortical activity and brain expression of genes associated with psychiatric illness |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189589/ https://www.ncbi.nlm.nih.gov/pubmed/34108214 http://dx.doi.org/10.1126/sciadv.abg1512 |
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