Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation

Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Given evidence of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and h...

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Detalles Bibliográficos
Autores principales: Xian, Hongxu, Liu, Yuan, Rundberg Nilsson, Alexandra, Gatchalian, Raphaella, Crother, Timothy R., Tourtellotte, Warren G., Zhang, Yi, Aleman-Muench, German R., Lewis, Gavin, Chen, Weixuan, Kang, Sarah, Luevanos, Melissa, Trudler, Dorit, Lipton, Stuart A., Soroosh, Pejman, Teijaro, John, de la Torre, Juan Carlos, Arditi, Moshe, Karin, Michael, Sanchez-Lopez, Elsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8189765/
https://www.ncbi.nlm.nih.gov/pubmed/34115964
http://dx.doi.org/10.1016/j.immuni.2021.05.004

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